DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and mecom

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_017206701.1	Gene:	mecom / 497407	ZFINID:	ZDB-GENE-050208-123	Length:	1257	Species:	Danio rerio

Alignment Length:	545	Identity:	159/545 - (29%)
Similarity:	224/545 - (41%)	Gaps:	155/545 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 YPALGLIP------TSYISHVPYDLASSASVAATSSSSTSPTTTSATTTGRLQHQH--------- 70
            :||.||:|      |:....|...:.:.||:|.....||..........|.|.:..
Zfish   660 FPAPGLLPPSLDEQTAVSGAVNDSIKAIASIAEKYFGSTGLAGLQDKKVGALPYPSMFPLSFFPA 724

  Fly    71 ---------SHQQHQTLNHHAKGKRRS-----------SFDQPLDLRLAHKRKTDLVDQGPMEDE 115
                     ..:|.:...|  ||:..|           :.:.|.||....|.:.......|::.|
Zfish   725 FSPSVYPFPEREQLRPPGH--KGEPESPPVESKKPQGRNAESPFDLTTKRKEERLAATCAPVKPE 787

  Fly   116 NSNLIMFASELAVAQQKEKELNNNHIAASLADLGFDMSRKMLRALREGGAGGGGGGGGGGGGGGG 180
            .|                      |:.::..|...|:|           .|....|....|....
Zfish   788 AS----------------------HVQSTNQDQPLDLS-----------LGRRNRGKSERGEEIK 819

  Fly   181 PPNA---------PPLTPPQCSIPAVHPTLLEAMTK------NLPLQYRNVFAGVLPGKVNSPAA 230
            ..:|         ||.|.|........|..::.:.:      |.|.:       ||..|...||
Zfish   820 KSSAFSEERVEPEPPKTDPSLQHARPMPFFMDPIYRVEKRKMNDPFE-------VLKDKYMRPA- 876

  Fly   231 SSSPTGADFP-FRHPLKKCELTWPPPTEQLQLELPHPNPKLSPVLPH--------PQLQDYQTRR 286
               |.....| ||.|.::   ||....|.:..:|    ...|.:.|.        |.:.|::...
Zfish   877 ---PGFLFHPQFRMPDQR---TWMSAIENMAEKL----ESFSSLKPDGGDIMRSVPSMFDFRAPP 931

  Fly   287 KNKARTAATGGNATPNLPQRNKDRYTCKFCGKVFPRSANLTRHLRTHTGEQPYKCKYCERSFSIS 351
            .....|          |.::.|:||||::|||:.|||||||||||||||||||:||||:||||||
Zfish   932 TTLPET----------LLRKGKERYTCRYCGKIXPRSANLTRHLRTHTGEQPYRCKYCDRSFSIS 986

  Fly   352 SNLQRHVRNIHNKERPFKCEICERCFGQQTNLDRHLKKHESDAVSLSALSGVSERMHCIRRFCEN 416
            ||||||:|||||||:||||.:|:|||||||||||||||||:..::.:|:|.....:.......|:
Zfish   987 SNLQRHIRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGNLAGTAMSSPRSELDSSSAILED 1051

  Fly   417 PTEESYFEEIRSFMGKVTQQQQQQQQQQQHDQQQQQHQSTATSASSSCSSSRDTPTSSHEEADHA 481
             .|:|||.|||:|:                       .:||.:|:|. |.|.:....||.:.|.|
Zfish  1052 -KEDSYFNEIRNFI-----------------------SNTARNATSP-SQSEEGLNGSHFDGDKA 1091

  Fly   482 PATSTADTAAPSSSRDQEEEDSQPI 506
                    .:...|||.:||:.:.:
Zfish  1092 --------LSGQGSRDLDEEEGEEL 1108

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	47/62 (76%)
		zf-C2H2	311..333	CDD:278523	17/21 (81%)
		C2H2 Zn finger	313..333	CDD:275368	15/19 (79%)
		zf-H2C2_2	325..349	CDD:290200	21/23 (91%)
		C2H2 Zn finger	341..362	CDD:275368	18/20 (90%)
		zf-H2C2_2	353..377	CDD:290200	18/23 (78%)
		zf-C2H2	368..390	CDD:278523	18/21 (86%)
		C2H2 Zn finger	370..390	CDD:275368	16/19 (84%)
mecom	XP_017206701.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D254483at33208
OrthoFinder	1	1.000	-	-		FOG0002720
OrthoInspector	1	1.000	-	-		otm25968
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010