DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and AgaP_AGAP000286

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_001237313.3	Gene:	AgaP_AGAP000286 / 4576068	VectorBaseID:	AGAP000286	Length:	533	Species:	Anopheles gambiae

Alignment Length:	405	Identity:	77/405 - (19%)
Similarity:	139/405 - (34%)	Gaps:	122/405 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 QHQHSHQQHQTLNHHAK---------GKRRSSFDQ--PLDLRLAHKRKTDLVDQGPMEDENSNLI 120
            :|...|||.|..:...|         |.:....:|  | |..:..:....|.:|.|...:...|
Mosquito   154 EHLEEHQQEQQQDEVDKTSGSETRRPGPQSGRLEQCEP-DPEILLEITKFLEEQTPRLPDGGRL- 216

  Fly   121 MFASELAVAQQKEKELNNNHIAASLADLGFDMSRKMLRALREGGAGGGGGGGGGGGGGGGPPNAP 185
             .|:|..|.|::...|     ...|:|:..:::...|:||                   |..|..
Mosquito   217 -DATEHVVEQRRRCGL-----CCVLSDVTLELTSDQLKAL-------------------GAFNVD 256

  Fly   186 PLTPPQCSIPAVHPTLLEAMTKNLPL--------------------------------QYRNVFA 218
            . ||..|....:...::::..|...:                                ...:.||
Mosquito   257 K-TPQVCEECCILLDIVDSFRKTTTIARELSGQEQRALDVLQLDSALEQAKCLASKLRHKHDAFA 320

  Fly   219 GV--LPGKVNSPAASSSPTGADFPFRHPLKKCELT----------WPPPTEQLQLEL-PHPNPKL 270
            |:  ..|.:|:.:.:|||.......|...|:.::|          |     :||..| .|.|.:
Mosquito   321 GLQYSGGSMNASSTTSSPAERQSVPRKAYKRAKVTCHICGKQYDSW-----KLQTHLNEHENIR- 379

  Fly   271 SPVLPHPQLQDYQ------------TRRKNKART-------------AATGGNATPNLPQRNKDR 310
                  |.:.|.:            .|.|....|             ..|.|....:|....:.:
Mosquito   380 ------PYVCDQEGCSSTFAGLVLLNRHKKLWHTDYFYAVCNVCGKKCKTQGIYKTHLSYHEEPK 438

  Fly   311 YTCKFCGKVFPRSANLTRHLRTHTGEQPYKCKYCERSFSISSNLQRHVRNIHNKERPFKCEICER 375
            ..|..|||:......:.:|::||:.::.:.|..|.:.|:|:..|:.|:| ||..::|:.|..|::
Mosquito   439 LPCTVCGKLMRNKRAIWKHMKTHSNDRKHVCGVCNKRFTIAYTLRVHMR-IHTNDKPYPCADCDK 502

  Fly   376 CFGQQTNLDRHLKKH 390
            .|..:..|..|.:::
Mosquito   503 RFQYKCLLKNHCRRY 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	16/62 (26%)
		zf-C2H2	311..333	CDD:278523	5/21 (24%)
		C2H2 Zn finger	313..333	CDD:275368	5/19 (26%)
		zf-H2C2_2	325..349	CDD:290200	5/23 (22%)
		C2H2 Zn finger	341..362	CDD:275368	7/20 (35%)
		zf-H2C2_2	353..377	CDD:290200	8/23 (35%)
		zf-C2H2	368..390	CDD:278523	5/21 (24%)
		C2H2 Zn finger	370..390	CDD:275368	5/19 (26%)
AgaP_AGAP000286	XP_001237313.3	zf-AD	15..87	CDD:285071
		C2H2 Zn finger	356..375	CDD:275368	4/23 (17%)
		C2H2 Zn finger	441..461	CDD:275368	5/19 (26%)
		C2H2 Zn finger	469..489	CDD:275368	7/20 (35%)
		zf-H2C2_2	482..504	CDD:290200	8/22 (36%)
		C2H2 Zn finger	497..518	CDD:275368	5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910