DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and egr3

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001002647.1	Gene:	egr3 / 436920	ZFINID:	ZDB-GENE-040718-394	Length:	422	Species:	Danio rerio

Alignment Length:	391	Identity:	92/391 - (23%)
Similarity:	131/391 - (33%)	Gaps:	150/391 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 PMEDENSNLIMFASELAVAQQKEKELNNNHIAASLADLGFDMSRKMLRALREGGAGGGGG---GG 172
            |.||..:::.:|.:..:::...:...:|      :.|||.            ||..|.|.   |.
Zfish    26 PEEDIPTSMNIFTNPDSISHYSQMNTDN------IMDLGM------------GGEKGSGEIQYGS 72

  Fly   173 GGGGGGGGPPNAPPL------TPPQCSI------PAVHPTLLEAMTKNLPLQYRNVFAGVL---- 221
            |....|........|      |||..||      |..:...|             |.||:|
Zfish    73 GSFQSGRSGQTVTYLGKFAFDTPPSGSIGGSGWCPDNNIISL-------------VSAGILGVSP 124

  Fly   222 -PGKVNSPAASSSPT----GADFP--FRHPL---KKCELTWPPPTEQLQLELPHPNPKLSPVLPH 276
             ||.:.:..:|||.:    .:|..  :..||   ..|...:|   ||:..   |.:|..|..||:
Zfish   125 SPGNITTQTSSSSGSMGGQSSDMEQVYAPPLPAYSTCGEIYP---EQVTF---HHSPATSSSLPY 183

  Fly   277 PQLQDYQT--------------------------------------------------------R 285
            |. .||.|                                                        :
Zfish   184 PS-SDYHTTSKPGMDGSLFSMIPDYNLFHHQGDVGVMEHKPFQTMDPIRVNPPPITPLETIRAFK 247

  Fly   286 RKNKARTAATGG---------------------NATPNLPQR---NKDRYTC--KFCGKVFPRSA 324
            .|.:......||                     ...||.|.:   ::..:.|  :.|.:.|.||.
Zfish   248 DKQQIHPGFLGGQQHVSQHHQPSQTLALKPIRPRKYPNRPSKTPVHERPHACPAENCDRRFSRSD 312

  Fly   325 NLTRHLRTHTGEQPYKCKYCERSFSISSNLQRHVRNIHNKERPFKCEICERCFGQQTNLDRHLKK 389
            .||||||.|||.:|::|:.|.||||.|.:|..|:|. |..|:||.||.|.|.|.:.....||.|.
Zfish   313 ELTRHLRIHTGHKPFQCRICMRSFSRSDHLTTHIRT-HTGEKPFSCEFCGRKFARSDERKRHAKV 376

  Fly   390 H 390
            |
Zfish   377 H 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	28/67 (42%)
		zf-C2H2	311..333	CDD:278523	11/23 (48%)
		C2H2 Zn finger	313..333	CDD:275368	11/21 (52%)
		zf-H2C2_2	325..349	CDD:290200	14/23 (61%)
		C2H2 Zn finger	341..362	CDD:275368	10/20 (50%)
		zf-H2C2_2	353..377	CDD:290200	11/23 (48%)
		zf-C2H2	368..390	CDD:278523	9/21 (43%)
		C2H2 Zn finger	370..390	CDD:275368	8/19 (42%)
egr3	NP_001002647.1	DUF3446	88..158	CDD:288757	19/82 (23%)
		C2H2 Zn finger	299..321	CDD:275368	11/21 (52%)
		zf-H2C2_2	313..338	CDD:290200	15/24 (63%)
		COG5048	325..>405	CDD:227381	24/54 (44%)
		C2H2 Zn finger	329..349	CDD:275368	10/20 (50%)
		zf-H2C2_2	341..366	CDD:290200	12/25 (48%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910