DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10348 and CG12942

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_610628.2	Gene:	CG12942 / 36158	FlyBaseID:	FBgn0033569	Length:	686	Species:	Drosophila melanogaster

Alignment Length:	578	Identity:	104/578 - (17%)
Similarity:	180/578 - (31%)	Gaps:	198/578 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PKQGCVYPALGLIPTSYISHVPYDLASSASVAATSSSSTSPTTTSATTTGRLQHQHS------HQ 73
            |.|.||.....|....:.  |...|.|:..:.|.:.|...|     :.||.|:.:.|      :|
  Fly    71 PMQICVRCCRALEVAMHF--VEMALESNLKLQAEAKSVKLP-----SPTGELKRKASNETIPWNQ 128

  Fly    74 QHQTLNHHAKGKRRSSFDQPLDLRLAHKRKTDL--------------------------VDQGPM 112
            ..|......:|     ::.|::..:.:.|.|.:                          .|...:
  Fly   129 FSQEFEQFVEG-----YEGPIEENVLYMRGTKVPRLDVDASSSSETAPKEDEVILFDVKYDTNDL 188

  Fly   113 EDENSN----------------------LIMFASELAVAQQKEKELNNNHIAASLADLGFDMSRK 155
            |:|:.|                      :::..:|.||........||.:  ..:.|...|:.::
  Fly   189 EEEDENDGSDAKNNETFFENSITPGESVMVVSVAEKAVENNNNYNFNNKN--GDVTDEECDLIQR 251

  Fly   156 MLR-ALREGGAGGGGGGGGGGGGGGGPPNAPPLTPPQCSIPAVHPTLLEAMTKNLPLQYRNVFAG 219
            .|. .|.:.|                           ||....:....|...|:..::
  Fly   252 ALEMTLNDDG---------------------------CSQSPKNEASNETQLKSNGIE------- 282

  Fly   220 VLPGKVNSP-----AASSSPTGADFPFRHPLKKCELTWPPPTEQLQLEL---------------- 263
                 |:||     |.:||.||     ..|:.||.:.....|:..||::
  Fly   283 -----VSSPLFIKLATTSSTTG-----NIPILKCNICQYTHTDAEQLKIHYKSIHKISMMEDDII 337

  Fly   264 ---PHPNPKLSP---------------VLPHPQL---------------------QDYQTRRKNK 289
               .:.|.|..|               ::.|.::                     :|.::.||:.
  Fly   338 GLNKNQNFKCRPCNSYETKDRSEMQKHLIDHHKIDGDFEMYCYMQANCPACDRIFKDQRSARKHY 402

  Fly   290 ARTAATGGNATP-NLPQRNKDRYTCKFCGKVFPRSANLTRHLRTHTGEQPYKCKYCERSFSISSN 353
            .|.      .|| .:.....:.|.|..|.|||.:.|:|..|.|....:....|.:|::.|:....
  Fly   403 TRV------HTPVQIAVSPTESYACTACDKVFNQKASLHSHQRFCQVKDVVHCSFCDQQFNSMRK 461

  Fly   354 LQRHVRNIHNKERPFKCEICERCFGQQTNLDRHLKKH-----ESDAVSLSALSGVSERMHCIRRF 413
            .:.|::.:|..|...:||||.|.|.....|..|.|:|     :....||:.::....|:|..|..
  Fly   462 YELHLQQLHAVETVHECEICRRSFKSAETLTMHRKRHSERHYQCGKCSLNYVNSAELRVHYERAH 526

  Fly   414 C-ENPTEESYFEEIRSFMGKVTQQQQQQQQQQQHDQQQQQHQSTATSASSSCSSSRDT 470
            . |.|            :..:|...|.|......:.:|:.||.:.......|:....|
  Fly   527 VNEEP------------VSCLTCGNQFQNMTLLREHEQRSHQKSKVWRCEVCNFETKT 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	16/63 (25%)
		zf-C2H2	311..333	CDD:278523	10/21 (48%)
		C2H2 Zn finger	313..333	CDD:275368	9/19 (47%)
		zf-H2C2_2	325..349	CDD:290200	5/23 (22%)
		C2H2 Zn finger	341..362	CDD:275368	4/20 (20%)
		zf-H2C2_2	353..377	CDD:290200	8/23 (35%)
		zf-C2H2	368..390	CDD:278523	9/21 (43%)
		C2H2 Zn finger	370..390	CDD:275368	9/19 (47%)
CG12942	NP_610628.2	zf-AD	22..101	CDD:285071	8/31 (26%)
		C2H2 Zn finger	385..406	CDD:275368	4/26 (15%)
		C2H2 Zn finger	421..470	CDD:275368	13/48 (27%)
		C2H2 Zn finger	449..466	CDD:275371	3/16 (19%)
		C2H2 Zn finger	478..498	CDD:275368	9/19 (47%)
		C2H2 Zn finger	505..526	CDD:275368	5/20 (25%)
		C2H2 Zn finger	534..555	CDD:275368	4/20 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910