DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and ZNF774

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001004309.2	Gene:	ZNF774 / 342132	HGNCID:	33108	Length:	483	Species:	Homo sapiens

Alignment Length:	421	Identity:	106/421 - (25%)
Similarity:	150/421 - (35%)	Gaps:	129/421 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 GGGGGGGGPPNAPPLTPPQCSIPAVHPTLLEAMTKNLPLQYRNVFAGVLPGKVNSPAASSSPTGA 237
            |..|..|.|.:.......:|     ||..||..              .|.| ::.|:..|.|...
Human     4 GTSGKSGLPGHCLENPLQEC-----HPAQLEEW--------------ALKG-ISRPSVISQPEQK 48

  Fly   238 DFPFRHPLKK-------------CE-------------------------------LTWPPPTEQ 258
            :.|:..||:.             ||                               |:|....||
Human    49 EEPWVLPLQNFEARKIPRESHTDCEHQVAKLNQDNSETAEQCGTSSERTNKDLSHTLSWGGNWEQ 113

  Fly   259 -LQLELPHPNPKLSPVLP-HPQLQDY-QTRRKNKARTAATG--------GNA-------TPNLPQ 305
             |:||..|      ..|| ..||:.: |.|..||......|        |.:       ..:|..
Human   114 GLELEGQH------GTLPGEGQLESFSQERDLNKLLDGYVGEKPMCAECGKSFNQSSYLIRHLRT 172

  Fly   306 RNKDR-YTCKFCGKVFPRSANLTRHLRTHTGEQPYKCKYCERSFSISSNLQRHVRNIHNKERPFK 369
            ...:| |||..|||.|.:|::|..|.||||||:||:||.||:.||.||.|.:|.|. |..|||::
Human   173 HTGERPYTCIECGKGFKQSSDLVTHRRTHTGEKPYQCKGCEKKFSDSSTLIKHQRT-HTGERPYE 236

  Fly   370 CEICERCFGQQTNLDRHLKKHESD----------AVSLSALSGVSERMHC-IRRFCENPTEESYF 423
            |..|.:.||::.:|..|.:.|..:          :.|.|:.....:|.|. ::.:..|...||:
Human   237 CPECGKTFGRKPHLIMHQRTHTGEKPYACLECHKSFSRSSNFITHQRTHTGVKPYRCNDCGESF- 300

  Fly   424 EEIRSFMGKVTQQQQQQQQQQQHDQQQQQHQSTATSASSSCSSS-RDTPTSSHEEADHAPATSTA 487
                             .|.....:.|:.|..........|... ||   |||..|.    .||.
Human   301 -----------------SQSSDLIKHQRTHTGERPFKCPECGKGFRD---SSHFVAH----MSTH 341

  Fly   488 DTAAPSSSRDQEEEDSQP--IMELKRTLTSK 516
            ....|.|..|..:..||.  ::..:||.|.:
Human   342 SGERPFSCPDCHKSFSQSSHLVTHQRTHTGE 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	31/63 (49%)
		zf-C2H2	311..333	CDD:278523	11/21 (52%)
		C2H2 Zn finger	313..333	CDD:275368	9/19 (47%)
		zf-H2C2_2	325..349	CDD:290200	14/23 (61%)
		C2H2 Zn finger	341..362	CDD:275368	11/20 (55%)
		zf-H2C2_2	353..377	CDD:290200	9/23 (39%)
		zf-C2H2	368..390	CDD:278523	6/21 (29%)
		C2H2 Zn finger	370..390	CDD:275368	6/19 (32%)
ZNF774	NP_001004309.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..101		0/19 (0%)
		COG5048	152..483	CDD:227381	70/247 (28%)
		C2H2 Zn finger	153..173	CDD:275368	2/19 (11%)
		zf-H2C2_2	165..190	CDD:290200	9/24 (38%)
		C2H2 Zn finger	181..201	CDD:275368	9/19 (47%)
		zf-H2C2_2	193..217	CDD:290200	14/23 (61%)
		C2H2 Zn finger	209..229	CDD:275368	11/20 (55%)
		zf-H2C2_2	222..246	CDD:290200	10/24 (42%)
		C2H2 Zn finger	237..257	CDD:275368	6/19 (32%)
		zf-H2C2_2	249..274	CDD:290200	3/24 (13%)
		C2H2 Zn finger	265..285	CDD:275368	3/19 (16%)
		zf-H2C2_2	277..302	CDD:290200	5/42 (12%)
		zf-C2H2	291..313	CDD:278523	5/39 (13%)
		C2H2 Zn finger	293..313	CDD:275368	5/37 (14%)
		zf-H2C2_2	305..328	CDD:290200	3/22 (14%)
		C2H2 Zn finger	321..341	CDD:275368	8/26 (31%)
		zf-C2H2	347..369	CDD:278523	5/21 (24%)
		C2H2 Zn finger	349..369	CDD:275368	4/19 (21%)
		zf-H2C2_2	361..385	CDD:290200	3/12 (25%)
		C2H2 Zn finger	377..397	CDD:275368
		zf-H2C2_2	389..414	CDD:290200
		C2H2 Zn finger	405..425	CDD:275368
		zf-H2C2_2	417..442	CDD:290200
		zf-C2H2	431..453	CDD:278523
		C2H2 Zn finger	433..453	CDD:275368
		zf-H2C2_2	445..470	CDD:290200
		C2H2 Zn finger	461..481	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910