DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10348 and zld

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001285466.1	Gene:	zld / 32994	FlyBaseID:	FBgn0259789	Length:	1596	Species:	Drosophila melanogaster

Alignment Length:	688	Identity:	136/688 - (19%)
Similarity:	237/688 - (34%)	Gaps:	235/688 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 HSPRKMLPSPKQGCVY----------PALGLIPTSYISH--------VPYDLASSASVAATSSSS 52
            :||..:....:||..:          |.:|::|...:.:        :|......:::...||:|
  Fly   914 NSPHTIYRQEQQGTDFSRTTPPPQPLPPMGMLPPMAMDYNMLALDMPMPMPTLMHSNMLQCSSTS 978

  Fly    53 TSPTTTSATTT---------GRLQHQHS------HQ------QHQTLNHHAKGKRRSSFDQPLDL 96
            |:|..|:.||:         .:|.|.:.      ||      |.|..:||.:.:.....||
  Fly   979 TTPLATTITTSMPDTMQPPQQQLVHHYQAVLHPLHQQLGEQHQRQEADHHQQQRELHQLDQ---- 1039

  Fly    97 RLAHKRKTDLVDQGPMEDEN-------SNLIMFASELAVAQQKEKELNNNHIAASLADLGFDMSR 154
            :...::...|.|..|....:       ..:.|..:.:...|....:....||.:::     .|..
  Fly  1040 QQQQQQALILADSLPHSSSSPTSSSPPPTMPMPLTTITAPQLLPLQPPPPHITSTM-----PMPP 1099

  Fly   155 KMLRALREGGAGGGGGGGGGGGGGGGPPNAPPLTPPQC--SIPAVHPTLL---------EAMT-- 206
            .|                       ..|..||  ||||  .:..:.||:.         ||.|
  Fly  1100 TM-----------------------HMPIMPP--PPQCYQQLQPLDPTMSYHTIIGSGPEAHTGT 1139

  Fly   207 --------------KNLPLQYRNVFAGVLPGKVNSPAASSSPTGADFPFRHPLKKC--------- 248
                          :.|.|...::||...|....|.||..||...|.|..|.|...
  Fly  1140 AGGGYSNQITTSDGQILQLMPTSLFAPYAPLSPYSVAAQRSPQEGDLPPVHTLTTALHAHQQGGQ 1204

  Fly   249 ---------ELTWP-PPT--------------------------EQLQLELPHPNPKLSPVLPHP 277
                     .|:.| .||                          ||.|::    :.:|..:..|.
  Fly  1205 QEAQTPTLTVLSTPYSPTVSSSRATPALEMDMATLMQHHQDYEMEQYQMQ----HQQLDQMQQHQ 1265

  Fly   278 QLQDYQTRRK---NKARTAA--------TGGNATPNLPQRNKD----------------RYTCKF 315
            |..|:|.:::   ::.:|.|        .||||||:..:|.::                |..|..
  Fly  1266 QQLDHQQQQQILADQTQTMAQQPLAKKRRGGNATPSTTKRRRNSSVGSTSPHSTTLPSGRIKCLE 1330

  Fly   316 CGKVFPRSANLTRHLRT-HTGEQPYKCKYCERSFSISSNLQRHVRNIHNKERPFKCEICERCFGQ 379
            |.|.|.::..||:|.:: |:||.|::|:.|.:.|........|:.....:::|.|||:|.:.|..
  Fly  1331 CDKEFTKNCYLTQHNKSFHSGEYPFRCQKCGKRFQSEDVYTTHLGRHRTQDKPHKCELCPKQFHH 1395

  Fly   380 QTNLDRH-------LKKHESDAVSLSALSGVSERMHCIRRFCENPTEESYFEEIRSFMGKVTQQQ 437
            :|:|.||       ||:|..|.              |.:.||..       :.:|..:
  Fly  1396 KTDLRRHVEAIHTGLKQHMCDI--------------CEKGFCRK-------DHLRKHL------- 1432

  Fly   438 QQQQQQQQHDQQQQQHQSTATSASSSCSSSRDTPTSSHEEADHAPATSTADTAAPSSSRDQEEED 502
                  :.|::.:...:.:|.:|:::.:::..|.|:.   ...|||..:. .||.:.|.......
  Fly  1433 ------ETHNRPRVVGKKSAAAAAAAAAAAAVTATAG---LGGAPAAGSI-KAAFARSLTVTAVS 1487

  Fly   503 SQP---IMELKRTLTSKLFPTTTADSAM---TTPQTTS 534
            |:|   :.......|:...|.:.:.||:   ..|..||
  Fly  1488 SEPGAGVAIPSAPATATCAPVSVSASALVQAVNPSLTS 1525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	19/79 (24%)
		zf-C2H2	311..333	CDD:278523	7/22 (32%)
		C2H2 Zn finger	313..333	CDD:275368	7/20 (35%)
		zf-H2C2_2	325..349	CDD:290200	9/24 (38%)
		C2H2 Zn finger	341..362	CDD:275368	4/20 (20%)
		zf-H2C2_2	353..377	CDD:290200	6/23 (26%)
		zf-C2H2	368..390	CDD:278523	11/28 (39%)
		C2H2 Zn finger	370..390	CDD:275368	10/26 (38%)
zld	NP_001285466.1	zf-C2H2_jaz	552..577	CDD:288983
		LIM	1328..1389	CDD:259829	19/60 (32%)
		C2H2 Zn finger	1328..1349	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1357..1377	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1386..1407	CDD:275368	8/20 (40%)
		zf-H2C2_2	1398..1422	CDD:290200	8/37 (22%)
		zf-C2H2	1413..1435	CDD:278523	6/55 (11%)
		C2H2 Zn finger	1415..1435	CDD:275368	5/53 (9%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24393
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100