DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and AgaP_AGAP011963

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_552275.3	Gene:	AgaP_AGAP011963 / 3291462	VectorBaseID:	AGAP011963	Length:	983	Species:	Anopheles gambiae

Alignment Length:	622	Identity:	115/622 - (18%)
Similarity:	198/622 - (31%)	Gaps:	250/622 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 VPYDLASSASVAATSSSSTSPTTTSATTTGR------------LQHQHSHQQHQTLNHHAKGKRR 87
            || ::|::|...|..::....||...:|.|.            ||:.||.:..||.|........
Mosquito   421 VP-EVAAAAPEPAILTNGGDETTKQVSTVGETVEAAAAVADESLQNGHSDEVAQTTNLSPVAAVP 484

  Fly    88 SSFDQPLDLRLAHKRKTDLVDQGPMEDENSNLIMFASELAVAQQKEKELNNNHIAASLADLGFDM 152
            |...| .......|||:.     |..:|....:..:::.....      ||:..|..:.:|
Mosquito   485 SKLAQ-TSPSTGRKRKST-----PYHEEEEPSVPTSTDALAGS------NNSEPALPVKEL---- 533

  Fly   153 SRKMLRALREGGAGGGGGGGGGGGGGGGPPNAPPLTPPQCSIPAVHPTLLEAMTKNLPLQYRNVF 217
                                             .:.||...:...| ...:|.|:
Mosquito   534 ---------------------------------VVLPPAAKVKVEH-RAQKATTE---------- 554

  Fly   218 AGVLPGKVNSPAASSSPTGADFPFRHPLKKCELTWPPPTEQLQLELPHPN--PKLSPVLPHPQLQ 280
                  :..||....:| |.....|   :|..:| |..||..:.|.|.|:  .||:|
Mosquito   555 ------ETESPPTELAP-GQQLAKR---RKSSIT-PIATEATKQEKPDPDDPDKLTP-------- 600

  Fly   281 DYQTRRKNKARTAATG--------------GNATPNLPQRNKD-------RYTCKFCGKVFPRSA 324
             :::.:.....:..||              |.||   .:.:.|       |.:|::||:.|.::.
Mosquito   601 -FESAKVTVLESEMTGETHYTCTICGGQFTGKAT---IKEHLDTVHAAIKRRSCEYCGRTFLQTG 661

  Fly   325 NLTRHLRTHTGEQPYKCKYCERSFSI--SSNLQRHVRNIHNKE---------------------- 365
            :||||:|.|||::|:||...|.||:.  |.:|.:|||. ||::
Mosquito   662 DLTRHVRIHTGQRPFKCPVVECSFAFISSGDLHKHVRR-HNQQPMPKPHVCDQCGKDFERSYDLK 725

  Fly   366 -----------------------------------------RPFKCEICERCFGQQTNLDRHLKK 389
                                                     ||::||||.:.|...:|..:|.:.
Mosquito   726 RHKTMHAKSEPDFKGITCGVCGKVFARRDQFRAHTYRHIGYRPYQCEICGKSFTDPSNYSKHARL 790

  Fly   390 HESDAVSL------------SALSGVSERMHCIRRFC----------------ENPTEESYFEEI 426
            ||.|.|.:            ||:|  ....||.::..                :..::|...::.
Mosquito   791 HEMDGVEVVCNFCNRPFKNKSAIS--KHIFHCQQKMAGAATNNKGEKRDGASKKGASKEGGGKKS 853

  Fly   427 R-----------------SFMGKVTQQQQQQQQQQQHDQQQQQHQSTATSASSSCSSSRD----- 469
            |                 ..|.|..|::...:.:|.....:..|...|.:.:.:..:::.
Mosquito   854 RRVGVAIGYSKDGGASGGGMMVKPKQEKAADESEQPVVAMETSHGGAAMNGARTKQAAKKKHKRR 918

  Fly   470 ---TPTSSHEEADHAPATSTADTAAPSSSRDQEEEDS 503
               ||:|:.||          |........|.:::||
Mosquito   919 RMRTPSSTEEE----------DDEGEEEEMDDDDDDS 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	26/71 (37%)
		zf-C2H2	311..333	CDD:278523	9/21 (43%)
		C2H2 Zn finger	313..333	CDD:275368	9/19 (47%)
		zf-H2C2_2	325..349	CDD:290200	13/23 (57%)
		C2H2 Zn finger	341..362	CDD:275368	9/22 (41%)
		zf-H2C2_2	353..377	CDD:290200	12/86 (14%)
		zf-C2H2	368..390	CDD:278523	7/21 (33%)
		C2H2 Zn finger	370..390	CDD:275368	7/19 (37%)
AgaP_AGAP011963	XP_552275.3	C2H2 Zn finger	711..731	CDD:275368	0/19 (0%)
		zf-C2H2	742..763	CDD:278523	0/20 (0%)
		C2H2 Zn finger	743..763	CDD:275368	0/19 (0%)
		zf-H2C2_2	756..779	CDD:290200	6/22 (27%)
		zf-C2H2	769..791	CDD:278523	7/21 (33%)
		C2H2 Zn finger	771..791	CDD:275368	7/19 (37%)
		C2H2 Zn finger	800..817	CDD:275368	3/18 (17%)
		COG5048	<500..787	CDD:227381	67/369 (18%)
		C2H2 Zn finger	621..642	CDD:275368	4/23 (17%)
		C2H2 Zn finger	650..670	CDD:275368	9/19 (47%)
		zf-H2C2_2	662..689	CDD:290200	14/26 (54%)
		C2H2 Zn finger	678..700	CDD:275368	9/22 (41%)
		zf-C2H2	709..731	CDD:278523	0/21 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910