DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and Zfp819

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001014039.1	Gene:	Zfp819 / 308561	RGDID:	1309564	Length:	614	Species:	Rattus norvegicus

Alignment Length:	305	Identity:	74/305 - (24%)
Similarity:	120/305 - (39%)	Gaps:	85/305 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 LKKCELTWPPPT--EQLQLELPHPNPKLSPVLPHPQLQDYQTRRKNKARTAATGGNA-------- 299
            |:|.||::.|.|  |:.:.|.|.....|: ..|......::...|.|..|....|.:
  Rat   316 LQKSELSFHPGTSREETRYECPDCLKSLT-TSPSSLQAHHEAHTKQKPYTCHDCGKSFSYASHLK 379

  Fly   300 ------TPNLP-------------------QR---NKDRYTCKFCGKVFPRSANLTRHLRTHTGE 336
                  |...|                   ||   .:..|.|..|||:|..:::|.:|.|.||||
  Rat   380 VHLRIHTGERPYVCSDCGKAFSQKSVLTTHQRIHTGEKPYACSHCGKLFVYASDLRKHSRFHTGE 444

  Fly   337 QPYKCKYCERSFSISSNLQRHVRNIHNKERPFKCEICERCFGQQTNLDRHLKKHESD-------- 393
            :||:|:.|.:.||..|:|..| |.||..|:|:||..|.:.|.::::|..|.:.|..:
  Rat   445 KPYECRDCGKVFSNKSHLPVH-RRIHTGEKPYKCRDCGKSFRRKSHLQVHGRTHTGEKPYACPDC 508

  Fly   394 --AVSLSALSGVSERMHCIRRFCENPTEESYFEEIRSFMGK-VTQQQQQQQQQQQHDQQQ----- 450
              |.|.|::....:|:|        ..|..|   :.|..|| ::.:.|..:.|:.|..::
  Rat   509 GKAFSHSSVLSTHQRIH--------TGERPY---VCSDCGKAMSSKAQLSEHQRVHTGEKPFVCV 562

  Fly   451 ------------QQHQSTATS----ASSSCSSS--RDTPTSSHEE 477
                        |.|:.|.:.    ....|...  |.:..|||::
  Rat   563 ECGKAFGGRSSLQVHRRTHSGEKPFVCHKCGKGFLRKSQLSSHQQ 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	28/84 (33%)
		zf-C2H2	311..333	CDD:278523	9/21 (43%)
		C2H2 Zn finger	313..333	CDD:275368	8/19 (42%)
		zf-H2C2_2	325..349	CDD:290200	11/23 (48%)
		C2H2 Zn finger	341..362	CDD:275368	8/20 (40%)
		zf-H2C2_2	353..377	CDD:290200	10/23 (43%)
		zf-C2H2	368..390	CDD:278523	6/21 (29%)
		C2H2 Zn finger	370..390	CDD:275368	5/19 (26%)
Zfp819	NP_001014039.1	KRAB	27..81	CDD:214630
		C2H2 Zn finger	336..357	CDD:275368	3/21 (14%)
		COG5048	<346..538	CDD:227381	51/203 (25%)
		C2H2 Zn finger	365..385	CDD:275368	1/19 (5%)
		C2H2 Zn finger	393..413	CDD:275368	2/19 (11%)
		C2H2 Zn finger	421..441	CDD:275368	8/19 (42%)
		C2H2 Zn finger	449..469	CDD:275368	8/20 (40%)
		C2H2 Zn finger	477..497	CDD:275368	5/19 (26%)
		SFP1	<499..582	CDD:227516	16/93 (17%)
		C2H2 Zn finger	505..525	CDD:275368	4/19 (21%)
		C2H2 Zn finger	533..553	CDD:275368	5/19 (26%)
		C2H2 Zn finger	561..581	CDD:275368	2/19 (11%)
		zf-H2C2_2	573..598	CDD:404364	4/24 (17%)
		C2H2 Zn finger	589..609	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910