DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and Klf12

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_038949311.1	Gene:	Klf12 / 306110	RGDID:	1309204	Length:	491	Species:	Rattus norvegicus

Alignment Length:	417	Identity:	91/417 - (21%)
Similarity:	146/417 - (35%)	Gaps:	160/417 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PYDL-----------ASSASVAATSSSSTSPTTTSATTTGRLQHQHSHQQHQTLNHHAKGKRRSS 89
            |.||           |||:.|:.|:|:| ||::||.::                         ||
  Rat   170 PVDLSINKARTSPTAASSSPVSMTASAS-SPSSTSTSS-------------------------SS 208

  Fly    90 FDQPLDLRLAHKRKTDLVDQGPMEDENSNLIMFASELAVAQQKEKELNNNHIAASLADLGFDMSR 154
            ..:|                     .:|..::  :.::.|......|:...:.||.:.:|.....
  Rat   209 SSRP---------------------ASSPTVI--TSVSSASSSSTVLSPGPLVASASGMGGQQFL 250

  Fly   155 KMLRALREGGAGGGGGGGGGGGGGGGPPNAPPLTPPQCSIPAVHPTLLEAMTKNLPLQYRNVFAG 219
            .::..:                    ||:: |:......:..||  .:..:.:::|:.|..|.:
  Rat   251 HIIHPV--------------------PPSS-PMNLQSNKLSHVH--RIPVVVQSVPVVYTAVRS- 291

  Fly   220 VLPGKVN------------------------SPAASSSPTGADFPFRHPLKKCELTWPPPTEQLQ 260
              ||.||                        ||..|.|.:..|     .|....|.....|....
  Rat   292 --PGNVNNTIVVPLLEDGRSHGKAQMEPRGLSPRQSKSDSDDD-----DLPNVTLDSVNETGSTA 349

  Fly   261 LELP------HPNP----------------KLSPVLPHPQLQDYQTRRKNKARTAATGGNATPNL 303
            |.:.      ||:|                .:||      .....|||:.::.:
  Rat   350 LSIARAVQEVHPSPVSRVRGNRMNNQKFACSISP------FSIESTRRQRRSES----------- 397

  Fly   304 PQRNKDR-YTCKF--CGKVFPRSANLTRHLRTHTGEQPYKCKY--CERSFSISSNLQRHVRNIHN 363
            |...|.| :.|.|  |.||:.:|::|..|.||||||:||||.:  |...|:.|..|.||.|. |.
  Rat   398 PDSRKRRIHRCDFEGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHYRK-HT 461

  Fly   364 KERPFKCEICERCFGQQTNLDRHLKKH 390
            ..:||||..|:|.|.:..:|..|.::|
  Rat   462 GVKPFKCADCDRSFSRSDHLALHRRRH 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	28/67 (42%)
		zf-C2H2	311..333	CDD:278523	9/23 (39%)
		C2H2 Zn finger	313..333	CDD:275368	9/21 (43%)
		zf-H2C2_2	325..349	CDD:290200	13/25 (52%)
		C2H2 Zn finger	341..362	CDD:275368	8/22 (36%)
		zf-H2C2_2	353..377	CDD:290200	11/23 (48%)
		zf-C2H2	368..390	CDD:278523	8/21 (38%)
		C2H2 Zn finger	370..390	CDD:275368	6/19 (32%)
Klf12	XP_038949311.1	KLF12_N	116..313	CDD:410608	35/217 (16%)
		COG5048	<314..490	CDD:227381	56/198 (28%)
		C2H2 Zn finger	408..430	CDD:275368	9/21 (43%)
		C2H2 Zn finger	438..460	CDD:275368	8/22 (36%)
		zf-H2C2_2	452..477	CDD:404364	12/25 (48%)
		C2H2 Zn finger	468..488	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910