DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and wt1a

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_571121.1	Gene:	wt1a / 30245	ZFINID:	ZDB-GENE-980526-558	Length:	419	Species:	Danio rerio

Alignment Length:	415	Identity:	94/415 - (22%)
Similarity:	138/415 - (33%)	Gaps:	127/415 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 CVYPALGLIPTS--------YISHVPYDLASSASVAATSSSSTSPTTTSATTTGRLQHQHSHQQH 75
            |.|.|.|....|        ..|:.||  .|:...:.:||.:....|.:........|..||...
Zfish    92 CRYGAFGAPAASQPPPSQPRMFSNSPY--LSNCMDSQSSSRNQGYGTVAFDGASNYGHTPSHHTP 154

  Fly    76 QTLNHHAKGKRRSSFDQPLDLRLAHKRKTDLVDQGPMEDEN-------------SNLIMFASELA 127
            |..||        ||          |.:..:..|..|.|:.             |:....:..|.
Zfish   155 QFPNH--------SF----------KHEDSITQQSNMGDQQYPVPPPVYGCHTPSDSCTGSQALL 201

  Fly   128 VAQQKEKELNNNHIAASLADLGFDMSRKMLRALREGGAGGGGGGGGGGGGGGGPPNAPPLTPPQC 192
            :........|...:|:.|..:|::....:...::           ...||....|:.|
Zfish   202 LRNPYNSSDNLYQMASQLECMGWNPVNSLASTIK-----------SHPGGYESDPSTP------- 248

  Fly   193 SIPAVHPTLLEAMTKNLPLQYR----NVFAGV-----LPGKVNSPAASSSPTGADFPFRHPLKKC 248
                        |..:...|||    .||.|:     :|| :......|:.|....||......|
Zfish   249 ------------MVYSCSTQYRIHTHGVFRGLQDVRRVPG-ITPAIVRSTETNEKRPFMCAYPGC 300

  Fly   249 ELTWPPPTEQLQLELPHPNPKLSPVLPHPQLQDYQTRRKNKARTAATGGNATPNLPQRNKDRYTC 313
            ...:               .|||    |.|:..    ||:      ||           :..|.|
Zfish   301 NKRY---------------FKLS----HLQMHS----RKH------TG-----------EKPYQC 325

  Fly   314 KF--CGKVFPRSANLTRHLRTHTGEQPYKCKYCERSFSISSNLQRHVRNIHNK--ERPFKCE--I 372
            .|  ||:.|.||..|.||.|.|||.:|::|:.|:|.||.|.:|:.|.|....|  |:||.|.  .
Zfish   326 DFTDCGRRFSRSDQLKRHQRRHTGVKPFQCETCQRKFSRSDHLKTHTRTHTGKTSEKPFNCRWPN 390

  Fly   373 CERCFGQQTNLDRHLKKHESDAVSL 397
            |::.|.:...|.||...|:.:...|
Zfish   391 CQKKFARSDELVRHHNMHQRNLTKL 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	25/64 (39%)
		zf-C2H2	311..333	CDD:278523	12/23 (52%)
		C2H2 Zn finger	313..333	CDD:275368	11/21 (52%)
		zf-H2C2_2	325..349	CDD:290200	11/23 (48%)
		C2H2 Zn finger	341..362	CDD:275368	9/20 (45%)
		zf-H2C2_2	353..377	CDD:290200	9/27 (33%)
		zf-C2H2	368..390	CDD:278523	7/23 (30%)
		C2H2 Zn finger	370..390	CDD:275368	6/21 (29%)
wt1a	NP_571121.1	WT1	1..291	CDD:280348	45/249 (18%)
		COG5048	286..>411	CDD:227381	49/164 (30%)
		C2H2 Zn finger	298..317	CDD:275368	7/41 (17%)
		zf-H2C2_2	309..336	CDD:290200	12/47 (26%)
		C2H2 Zn finger	325..347	CDD:275368	11/21 (52%)
		zf-H2C2_2	340..364	CDD:290200	12/23 (52%)
		C2H2 Zn finger	355..375	CDD:275368	9/19 (47%)
		C2H2 Zn finger	386..408	CDD:275368	6/21 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910