DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and Sp4

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_036893.1	Gene:	Sp4 / 25162	RGDID:	3741	Length:	783	Species:	Rattus norvegicus

Alignment Length:	479	Identity:	98/479 - (20%)
Similarity:	174/479 - (36%)	Gaps:	135/479 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PALGLIPTSYISHVPYDLASSASVAATSSSSTSPTTTSATTTGRLQHQHSHQQHQTLNHHAKGKR 86
            |.....|.|.:...|....:..:.|:||.:| |.|..|:..||:.....:....:|:...
  Rat   303 PTTSTAPASTMPESPSSSTTCTTTASTSLTS-SDTLVSSADTGQYASTSASSSERTIEEP----- 361

  Fly    87 RSSFDQPLDLRLAHKRKTDLVDQG--PMEDENSNL--IMFASELAVAQQKEKELNNNHIAASLAD 147
                ..|.......:..:.|...|  ..:|::::|  :....: .:.||.:.:.....|..::..
  Rat   362 ----QTPAATESEAQSSSQLQSNGIQNAQDQSNSLQQVQIVGQ-PILQQIQIQQPQQQIIQAIPP 421

  Fly   148 LGFDM-SRKMLRALREGGAGGGGGGGGGGGGGGGPP----------------NAPPLTPP-QCSI 194
            ..|.: |.:.::.:::                  .|                .||.|||. |.|.
  Rat   422 QSFQLQSGQTIQTIQQ------------------QPLQNVQLQAVNPTQVLIRAPTLTPSGQISW 468

  Fly   195 PAVHPTLLEAMTKNLPLQYRNVFAGVLPGKVNSPAASSSPT-----------GADFPFRHPLKKC 248
            ..|....:::::.   ||.:|  ||:......:|.:||..|           ||..    .|...
  Rat   469 QTVQVQNIQSLSN---LQVQN--AGLSQQLTITPVSSSGGTTLAQIAPVAVAGAPI----TLNTA 524

  Fly   249 ELTWPPPTEQLQ--------LELPHPNPKLSPVLPHPQLQD-YQTRRKNKAR-TAATGG--NAT- 300
            :|...|..:.:.        :::......::.|....|.|| .:.::...|. |.|.||  |||
  Rat   525 QLASVPNLQTVSVANLGAAGVQVQGVPVTITSVAGQQQGQDGVKVQQATIAPVTVAVGGIANATI 589

  Fly   301 -------------------------------------PNLPQ---------RNKDRYTCKF--CG 317
                                                 ||..:         ..|.::.|..  ||
  Rat   590 GAVSPDQLTQVHLQQGQQTSDAEVQPGKRLRRVACSCPNCREGEGRGSSEPGKKKQHVCHIEGCG 654

  Fly   318 KVFPRSANLTRHLRTHTGEQPYKCK--YCERSFSISSNLQRHVRNIHNKERPFKCEICERCFGQQ 380
            ||:.::::|..|||.||||:|:.|.  :|.:.|:.|..|||| |..|..|:.|:|..|.:.|.:.
  Rat   655 KVYGKTSHLRAHLRWHTGERPFICNWMFCGKRFTRSDELQRH-RRTHTGEKRFECPECSKRFMRS 718

  Fly   381 TNLDRHLKKHESDAVSLSALSGVS 404
            .:|.:|:|.|::.....:||:.|:
  Rat   719 DHLSKHVKTHQNKKGGGTALAIVT 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	27/113 (24%)
		zf-C2H2	311..333	CDD:278523	9/23 (39%)
		C2H2 Zn finger	313..333	CDD:275368	9/21 (43%)
		zf-H2C2_2	325..349	CDD:290200	11/25 (44%)
		C2H2 Zn finger	341..362	CDD:275368	9/22 (41%)
		zf-H2C2_2	353..377	CDD:290200	10/23 (43%)
		zf-C2H2	368..390	CDD:278523	7/21 (33%)
		C2H2 Zn finger	370..390	CDD:275368	6/19 (32%)
Sp4	NP_036893.1	C2H2 Zn finger	648..670	CDD:275368	9/21 (43%)
		COG5048	<661..732	CDD:227381	28/71 (39%)
		zf-H2C2_2	662..689	CDD:290200	12/26 (46%)
		C2H2 Zn finger	678..700	CDD:275368	9/22 (41%)
		zf-H2C2_2	692..715	CDD:290200	10/23 (43%)
		zf-C2H2	706..728	CDD:278523	7/21 (33%)
		C2H2 Zn finger	708..728	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910