DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and Sp1

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_036787.2	Gene:	Sp1 / 24790	RGDID:	3738	Length:	786	Species:	Rattus norvegicus

Alignment Length:	463	Identity:	108/463 - (23%)
Similarity:	163/463 - (35%)	Gaps:	153/463 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 SSASVAATSSSSTS--------PTTTSATTTGRL------------QHQHSH------------- 72
            ||||:.::.:||:|        .|||:.:..|.:            |.|.|.
  Rat   307 SSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFTSSGSSGTSSQGQTSQRVGGLQGSDSLNI 371

  Fly    73 QQHQTLNHHAKGKRRSSFDQPLDLRLAHKRKTDLVDQGPMEDENSNLIMFASELAVAQQKEKELN 137
            ||:||.....:|.::...:|                   .:......|:...:|....|..:.|.
  Rat   372 QQNQTSGGSLQGSQQKEGEQ-------------------SQQTQQQQILIQPQLVQGGQALQALQ 417

  Fly   138 NNHIAASLADLGFD---MSRKMLRALREGGAGGGG---------GGGG----------------- 173
                ||.|:...|.   :|::.|:.|:.......|         |..|
  Rat   418 ----AAPLSGQTFTTQAISQETLQNLQLQAVQNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNP 478

  Fly   174 -----------GGGGGGGPPNAPPLTP--PQCSIPAVHPTLLEAMTKNLP-LQYRNVFA----GV 220
                       |...|....:...|||  ...||||...|:..|...::| ||..|:.|    |:
  Rat   479 QAQTITLAPMQGVSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQLSSMPGLQTINLSALGTSGI 543

  Fly   221 ----LPGK----VNSPAASSSPTGADFPFRHPLKKCELTWPPPTEQLQLELPHPNPKLSPVLPHP 277
                |||.    .|:|....:..|...|....:.. |.......|    ..|.|.|
  Rat   544 QVHQLPGLPLAIANTPGDHGAQLGLHGPGGDGIHD-ETAGGEEGE----NSPDPQP--------- 594

  Fly   278 QLQDYQTRRKNKARTAAT---------GGNATPNLPQRNKDRYTCKF--CGKVFPRSANLTRHLR 331
                 |..|:.: |.|.|         .|:..|.    .|.::.|..  ||||:.::::|..|||
  Rat   595 -----QAGRRTR-REACTCPYCKDSEGRGSGDPG----KKKQHICHIQGCGKVYGKTSHLRAHLR 649

  Fly   332 THTGEQPYKC--KYCERSFSISSNLQRHVRNIHNKERPFKCEICERCFGQQTNLDRHLKKHES-- 392
            .||||:|:.|  .||.:.|:.|..||||.|. |..|:.|.|..|.:.|.:..:|.:|:|.|::
  Rat   650 WHTGERPFMCNWSYCGKRFTRSDELQRHKRT-HTGEKKFACPECPKRFMRSDHLSKHIKTHQNKK 713

  Fly   393 --DAVSLS 398
              ..|:||
  Rat   714 GGPGVALS 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	26/66 (39%)
		zf-C2H2	311..333	CDD:278523	9/23 (39%)
		C2H2 Zn finger	313..333	CDD:275368	9/21 (43%)
		zf-H2C2_2	325..349	CDD:290200	12/25 (48%)
		C2H2 Zn finger	341..362	CDD:275368	10/22 (45%)
		zf-H2C2_2	353..377	CDD:290200	10/23 (43%)
		zf-C2H2	368..390	CDD:278523	7/21 (33%)
		C2H2 Zn finger	370..390	CDD:275368	6/19 (32%)
Sp1	NP_036787.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..94
		Repressor domain. /evidence=ECO:0000250	2..83
		SP1-4_N	55..628	CDD:425404	71/367 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..143
		Transactivation domain A (Gln-rich). /evidence=ECO:0000250	147..252
		Transactivation domain B (Gln-rich). /evidence=ECO:0000250	262..496		36/211 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..303
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..397		11/83 (13%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:P08047	463..471		0/7 (0%)
		Transactivation domain C (highly charged). /evidence=ECO:0000250	497..611		32/133 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	562..600		9/56 (16%)
		VZV IE62-binding. /evidence=ECO:0000250	620..786		39/107 (36%)
		zf-C2H2	627..651	CDD:395048	9/23 (39%)
		C2H2 Zn finger	629..651	CDD:275368	9/21 (43%)
		zf-H2C2_2	643..670	CDD:404364	13/26 (50%)
		C2H2 Zn finger	659..681	CDD:275368	10/22 (45%)
		zf-H2C2_2	673..696	CDD:404364	10/23 (43%)
		zf-C2H2	687..709	CDD:395048	7/21 (33%)
		C2H2 Zn finger	689..709	CDD:275368	6/19 (32%)
		Domain D. /evidence=ECO:0000250	709..786		4/13 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910