DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and Egr1

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_036683.1	Gene:	Egr1 / 24330	RGDID:	2544	Length:	508	Species:	Rattus norvegicus

Alignment Length:	521	Identity:	126/521 - (24%)
Similarity:	184/521 - (35%)	Gaps:	191/521 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 GAGG-----------GGGGGGGGGGGG------GPPNAPP---LTPPQCSIPAVH--PTLLEA-- 204
            |:||           |||||||...|.      |.|:..|   ||....|..|::  ..|:|.
  Rat    29 GSGGNNSSSSSSSSSGGGGGGGSNSGSSAFNPQGEPSEQPYEHLTTESFSDIALNNEKALVETSY 93

  Fly   205 ---MTKNLPLQYRNVFA-----------------GVLPGKVN------------SPAASSSPTGA 237
               .|:..|:.|...|:                 .::.|.|:            |||||||.:.:
  Rat    94 PSQTTRLPPITYTGRFSLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPTSSSSAPSPAASSSSSAS 158

  Fly   238 DFP---------FRHPLKKCELTWPPPTEQLQLE-------------LPHPNPKLS--------P 272
            ..|         ...|:.....|:|.|...:..|             |.:|.|...        |
  Rat   159 QSPPLSCAVPSNDSSPIYSAAPTFPTPNTDIFPEPQSQAFPGSAGTALQYPPPAYPATKGGFQVP 223

  Fly   273 VLP---HPQLQ----------------DYQTRRKN-------KARTAATGG------NAT----- 300
            ::|   .||.|                :.:|::.:       ||....:|.      |.|
  Rat   224 MIPDYLFPQQQGDLSLGTPDQKPFQGLENRTQQPSLTPLSTIKAFATQSGSQDLKALNNTYQSQL 288

  Fly   301 ---------PNLPQR---NKDRYTC--KFCGKVFPRSANLTRHLRTHTGEQPYKCKYCERSFSIS 351
                     ||.|.:   ::..|.|  :.|.:.|.||..||||:|.|||::|::|:.|.|:||.|
  Rat   289 IKPSRMRKYPNRPSKTPPHERPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRS 353

  Fly   352 SNLQRHVRNIHNKERPFKCEICERCFGQQTNLDRHLKKH--------ESDAVSLSALSGVSERMH 408
            .:|..|:|. |..|:||.|:||.|.|.:.....||.|.|        :...|:.||.|.:|.
  Rat   354 DHLTTHIRT-HTGEKPFACDICGRKFARSDERKRHTKIHLRQKDKKADKSVVASSAASSLSS--- 414

  Fly   409 CIRRFCENPTEESY-FEEIRSFMGKVTQQQQQQQQQQQHDQQQQQHQSTATSASSSCSSSRDTPT 472
                 ..:|...|| .....||...|                       .||.||..||:..:|.
  Rat   415 -----YPSPVATSYPSPATTSFPSPV-----------------------PTSYSSPGSSTYPSPA 451

  Fly   473 SSHEEADHAPATSTADTAAPSSSRDQEEEDSQPIMELKRTLTSKLFPTTTADSAMT---TPQTTS 534
            .|   ...:|:.:|...:.|.:...|       :...:....|..|.|:|..|.||   :|:|..
  Rat   452 HS---GFPSPSVATTYASVPPAFPAQ-------VSTFQSAGVSNSFSTSTGLSDMTATFSPRTIE 506

  Fly   535 I 535
            |
  Rat   507 I 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	28/81 (35%)
		zf-C2H2	311..333	CDD:278523	11/23 (48%)
		C2H2 Zn finger	313..333	CDD:275368	10/21 (48%)
		zf-H2C2_2	325..349	CDD:290200	12/23 (52%)
		C2H2 Zn finger	341..362	CDD:275368	9/20 (45%)
		zf-H2C2_2	353..377	CDD:290200	11/23 (48%)
		zf-C2H2	368..390	CDD:278523	9/21 (43%)
		C2H2 Zn finger	370..390	CDD:275368	8/19 (42%)
Egr1	NP_036683.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..78		16/48 (33%)
		DUF3446	107..182	CDD:288757	12/74 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..210		14/73 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..311		3/18 (17%)
		zf-C2H2	311..335	CDD:278523	11/23 (48%)
		C2H2 Zn finger	313..335	CDD:275368	10/21 (48%)
		zf-H2C2_2	327..352	CDD:290200	13/24 (54%)
		COG5048	338..>396	CDD:227381	23/58 (40%)
		C2H2 Zn finger	343..363	CDD:275368	9/20 (45%)
		zf-H2C2_2	355..380	CDD:290200	12/25 (48%)
		C2H2 Zn finger	371..391	CDD:275368	8/19 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..453		22/101 (22%)
		7 X 8 AA tandem repeats of [TS](2)-[FY]-[PS]-S-P-[GSAV]-X	413..468		17/88 (19%)
		DUF3432	420..495	CDD:288743	21/107 (20%)
		BES1_N	<424..453	CDD:283367	10/51 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910