DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and ZNF510

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001300988.1	Gene:	ZNF510 / 22869	HGNCID:	29161	Length:	683	Species:	Homo sapiens

Alignment Length:	440	Identity:	96/440 - (21%)
Similarity:	154/440 - (35%)	Gaps:	133/440 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 TTTGRLQHQHSHQQHQTLNHHAKGKRRSSFDQPLDLRLAHKRKTDLVDQGPMEDENSNLIMF-AS 124
            |.||...::| ::..:.||::....:...| |.|:      :..:....|...::.:|.:.. :|
Human   219 TQTGEKFYEH-NKNMKALNYNENLPKHPKF-QTLE------QAFECNKIGKAFNDKANCVKHNSS 275

  Fly   125 ELAVAQQKEKELNNNHIAASLADLGFDMSRKMLRALREGGAGGGGGGGGGGGGGGGPPNAPPLTP 189
            .......|:.|...|            ..:|.|...|..|.|                 ...|..
Human   276 HTGETSSKDDEFRKN------------CDKKTLFDHRRTGTG-----------------KKHLHL 311

  Fly   190 PQCSIPAVHPTLLEAMTKNLPLQYRNVFAGVLPGKVNSPAASSSPTGADFPFRHPLKKCELTWPP 254
            .||.         ::..|:...:|..:..|:...::|       |:|.:|.     :|..||.|
Human   312 NQCG---------KSFEKSTVEEYNKLNMGIKHYELN-------PSGNNFN-----RKAHLTDP- 354

  Fly   255 PTEQLQLELPHPNPKLSPVLP---------HPQLQDYQT-----RRKNKARTAATGGNATPNLPQ 305
                 |..:...||.:|....         |...:.|||     ||::.:....
Human   355 -----QTAVIEENPLVSNDRTQTWVKSSEYHENKKSYQTSVHRVRRRSHSMMKP----------- 403

  Fly   306 RNKDRYTCKFCGKVFPRSANLTRHLRTHTGEQPYKCKYCERSFSISSNLQRHVRNIHNKERPFKC 370
                 |.|..|||.|.:..:|.:|.||||||:|::|..|.::||..|:|..|.| ||..|:|:||
Human   404 -----YKCNECGKSFCQKGHLIQHQRTHTGEKPFECSECGKTFSQKSHLSTHQR-IHTAEKPYKC 462

  Fly   371 EICERCFGQQTNLDRHLKKHESDA-----------VSLSALSGVSERMHCIRRFCENPTEESYFE 424
            ..|.:.|.|::.|..|.:.|..:.           |..|.|.. ..|:|         |.|..|:
Human   463 NECGKTFVQKSTLRGHQRIHTGEKPYECSECGKTFVQKSTLRD-HHRIH---------TGEKSFQ 517

  Fly   425 ----------------EIRSFMGKVTQQQQQQQQQQQHDQQQQQHQSTAT 458
                            ..|:..|:.|.|..:.::.........|||.|.|
Human   518 CNQCGKTFGQKSNLRIHQRTHTGEKTYQCNECEKSFWRKDHLIQHQKTHT 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	24/62 (39%)
		zf-C2H2	311..333	CDD:278523	9/21 (43%)
		C2H2 Zn finger	313..333	CDD:275368	8/19 (42%)
		zf-H2C2_2	325..349	CDD:290200	11/23 (48%)
		C2H2 Zn finger	341..362	CDD:275368	8/20 (40%)
		zf-H2C2_2	353..377	CDD:290200	10/23 (43%)
		zf-C2H2	368..390	CDD:278523	7/21 (33%)
		C2H2 Zn finger	370..390	CDD:275368	6/19 (32%)
ZNF510	NP_001300988.1	KRAB	46..105	CDD:214630
		KRAB	46..85	CDD:279668
		COG5048	240..663	CDD:227381	90/418 (22%)
		C2H2 Zn finger	256..276	CDD:275368	2/19 (11%)
		zf-C2H2	404..426	CDD:278523	9/21 (43%)
		C2H2 Zn finger	406..426	CDD:275368	8/19 (42%)
		zf-H2C2_2	418..443	CDD:290200	12/24 (50%)
		C2H2 Zn finger	434..454	CDD:275368	8/20 (40%)
		zf-H2C2_2	446..471	CDD:290200	11/25 (44%)
		C2H2 Zn finger	462..482	CDD:275368	6/19 (32%)
		zf-H2C2_2	475..499	CDD:290200	3/23 (13%)
		C2H2 Zn finger	490..510	CDD:275368	4/20 (20%)
		zf-H2C2_2	503..525	CDD:290200	6/31 (19%)
		zf-C2H2	516..538	CDD:278523	2/21 (10%)
		C2H2 Zn finger	518..538	CDD:275368	1/19 (5%)
		zf-H2C2_2	530..555	CDD:290200	4/24 (17%)
		C2H2 Zn finger	546..566	CDD:275368	3/19 (16%)
		zf-H2C2_2	558..583	CDD:290200	5/10 (50%)
		C2H2 Zn finger	574..594	CDD:275368
		zf-H2C2_2	587..611	CDD:290200
		C2H2 Zn finger	602..622	CDD:275368
		zf-H2C2_2	615..637	CDD:290200
		zf-C2H2	628..650	CDD:278523
		C2H2 Zn finger	630..650	CDD:275368
		C2H2 Zn finger	658..676	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910