DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and Prdm9

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_036016343.1	Gene:	Prdm9 / 213389	MGIID:	2384854	Length:	854	Species:	Mus musculus

Alignment Length:	343	Identity:	78/343 - (22%)
Similarity:	132/343 - (38%)	Gaps:	110/343 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 VHPTLL--------EAMTKNLPLQYRNVFAGVLPGKVNSPAASSSPTGADFPFRHPLKKCELTWP 253
            :||.||        :.:|:::...:|   ..:.||    .:|..:|...|
Mouse   398 IHPCLLCSLAFSSQKFLTQHMEWNHR---TEIFPG----TSARINPKPGD--------------- 440

  Fly   254 PPTEQLQLELPH-------------------PNPKLSPVLP---HPQLQDYQTRRK-NKARTAAT 295
            |.::|||.:  |                   |..::|...|   ..|::..:::|. .:.||..|
Mouse   441 PCSDQLQEQ--HVDSQNKNDKASNEVKRKSKPRQRISTTFPSTLKEQMRSEESKRTVEELRTGQT 503

  Fly   296 GG------------------------NATPNLPQRNKDR-----YTCKFCGKVFPRSANLTRHLR 331
            ..                        :...|:.:..|..     |.|:.||:.|.::::|.:|.|
Mouse   504 TNTEDTVKSFIASEISSIERQCGQYFSDKSNVNEHQKTHTGEKPYVCRECGRGFTQNSHLIQHQR 568

  Fly   332 THTGEQPYKCKYCERSFSISSNLQRHVRNIHNKERPFKCEICERCFGQQTNLDRHLKKH--ESDA 394
            |||||:||.|:.|.|.|:..|:|.:|.|. |..|:|:.|..|.|.|.|:::|.:|.:.|  |...
Mouse   569 THTGEKPYVCRECGRGFTQKSDLIKHQRT-HTGEKPYVCRECGRGFTQKSDLIKHQRTHTGEKPY 632

  Fly   395 VSLSALSGVSERMHCIRRFCENPTEESYF--EEIRSFMGKVTQQQQQQQQQQQHDQQQQ------ 451
            |......|.:::...|:....:..|:.|.  |..|.|    ||:....:.|:.|..::.
Mouse   633 VCRECGRGFTQKSVLIKHQRTHTGEKPYVCRECGRGF----TQKSVLIKHQRTHTGEKPYVCREC 693

  Fly   452 -----------QHQSTAT 458
                       |||.|.|
Mouse   694 GRGFTAKSVLIQHQRTHT 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	25/67 (37%)
		zf-C2H2	311..333	CDD:278523	8/21 (38%)
		C2H2 Zn finger	313..333	CDD:275368	7/19 (37%)
		zf-H2C2_2	325..349	CDD:290200	13/23 (57%)
		C2H2 Zn finger	341..362	CDD:275368	8/20 (40%)
		zf-H2C2_2	353..377	CDD:290200	9/23 (39%)
		zf-C2H2	368..390	CDD:278523	7/21 (33%)
		C2H2 Zn finger	370..390	CDD:275368	7/19 (37%)
Prdm9	XP_036016343.1	SSXRD	186..212	CDD:401460
		PR-SET_PRDM7_9	251..379	CDD:380970
		C2H2 Zn finger	523..542	CDD:275368	2/18 (11%)
		COG5048	546..>851	CDD:227381	52/171 (30%)
		C2H2 Zn finger	550..570	CDD:275368	7/19 (37%)
		C2H2 Zn finger	578..598	CDD:275368	8/20 (40%)
		C2H2 Zn finger	606..626	CDD:275368	7/19 (37%)
		C2H2 Zn finger	634..654	CDD:275368	2/19 (11%)
		C2H2 Zn finger	662..682	CDD:275368	6/23 (26%)
		C2H2 Zn finger	690..710	CDD:275368	3/19 (16%)
		C2H2 Zn finger	718..738	CDD:275368
		C2H2 Zn finger	746..766	CDD:275368
		C2H2 Zn finger	774..794	CDD:275368
		C2H2 Zn finger	802..822	CDD:275368
		C2H2 Zn finger	830..850	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910