DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and EGR3

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_005273482.1	Gene:	EGR3 / 1960	HGNCID:	3240	Length:	442	Species:	Homo sapiens

Alignment Length:	275	Identity:	78/275 - (28%)
Similarity:	100/275 - (36%)	Gaps:	94/275 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 GGPP----------NAPPLTPPQCSIPAVHPTLLEAMTKNLPLQYRNVFAGVL------------ 221
            |.||          .|..:.|||..:.|::|.        || .|.|  .|.|
Human   167 GVPPASGALSTQTSTASMVQPPQGDVEAMYPA--------LP-PYSN--CGDLYSEPVSFHDPQG 220

  Fly   222 -PGKVNSPA-ASSSPTGAD---FP-------FRHPLKKCEL-------------TWPPPTEQLQL 261
             ||...||. ..|:....|   ||       :.||.....:             ..|||...|:.
Human   221 NPGLAYSPQDYQSAKPALDSNLFPMIPDYNLYHHPNDMGSIPEHKPFQGMDPIRVNPPPITPLET 285

  Fly   262 --------------ELPHPNPKLSPVLPHPQLQDYQTRRKNKARTAATGGNATPNLPQRNKDRYT 312
                          .||.|...|.|:.|          ||...|.:.|..:..|         :.
Human   286 IKAFKDKQIHPGFGSLPQPPLTLKPIRP----------RKYPNRPSKTPLHERP---------HA 331

  Fly   313 C--KFCGKVFPRSANLTRHLRTHTGEQPYKCKYCERSFSISSNLQRHVRNIHNKERPFKCEICER 375
            |  :.|.:.|.||..||||||.|||.:|::|:.|.||||.|.:|..|:|. |..|:||.||.|.|
Human   332 CPAEGCDRRFSRSDELTRHLRIHTGHKPFQCRICMRSFSRSDHLTTHIRT-HTGEKPFACEFCGR 395

  Fly   376 CFGQQTNLDRHLKKH 390
            .|.:.....||.|.|
Human   396 KFARSDERKRHAKIH 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	26/64 (41%)
		zf-C2H2	311..333	CDD:278523	11/23 (48%)
		C2H2 Zn finger	313..333	CDD:275368	11/21 (52%)
		zf-H2C2_2	325..349	CDD:290200	14/23 (61%)
		C2H2 Zn finger	341..362	CDD:275368	10/20 (50%)
		zf-H2C2_2	353..377	CDD:290200	11/23 (48%)
		zf-C2H2	368..390	CDD:278523	9/21 (43%)
		C2H2 Zn finger	370..390	CDD:275368	8/19 (42%)
EGR3	XP_005273482.1	DUF3446	142..202	CDD:288757	11/43 (26%)
		COG5048	324..>388	CDD:227381	28/73 (38%)
		zf-C2H2	330..354	CDD:278523	11/23 (48%)
		C2H2 Zn finger	332..354	CDD:275368	11/21 (52%)
		zf-H2C2_2	346..371	CDD:290200	15/24 (63%)
		COG5048	358..>431	CDD:227381	24/54 (44%)
		C2H2 Zn finger	362..382	CDD:275368	10/20 (50%)
		zf-H2C2_2	374..399	CDD:290200	12/25 (48%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910