Protein Alignment CG10348 and EGR1

DIOPT Version :9

• Sequence 1: NP_001286059.1
• Gene: CG10348 / 35132
• FlyBaseID: FBgn0032707
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_001955.1
• Gene: EGR1 / 1958
• HGNCID: 3238
• Length: 543
• Species: Homo sapiens
• Alignment Length: 540
• Identity: 120/540 - (22%)
• Similarity: 173/540 - (32%)
• Gaps: 214/540 - (39%)

  Fly   163 GGAGGGGGGG--------GGGGGGGGPPNA----------------------------------- 184
            |.||...|.|        ||||||||..|:
Human    50 GAAGAPEGSGSNSSSSSSGGGGGGGGGSNSSSSSSTFNPQADTGEQPYEHLTAESFPDISLNNEK 114

  Fly   185 --------------PPLT----------------------------------PPQCSIPAVHPTL 201
                          ||:|                                  ||..|..|..|..
Human   115 VLVETSYPSQTTRLPPITYTGRFSLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPASSSSAPSPAA 179

  Fly   202 LEAMTKNLPLQYRNVFAGVLPGKVNSPAASSSPTGADFP------FRHPLKKC-------ELTWP 253
            ..|.....|     ..:..:|...:||..|::||   ||      |..|..:.       .|.:|
Human   180 SSASASQSP-----PLSCAVPSNDSSPIYSAAPT---FPTPNTDIFPEPQSQAFPGSAGTALQYP 236

  Fly   254 PPT--------------------EQLQLELPHPN-------------PKLSPV------LPHPQL 279
            ||.                    :|..|.|..|:             |.|:|:      ......
Human   237 PPAYPAAKGGFQVPMIPDYLFPQQQGDLGLGTPDQKPFQGLESRTQQPSLTPLSTIKAFATQSGS 301

  Fly   280 QD-------YQTRRKNKARTAATGGNATPNLPQR---NKDRYTC--KFCGKVFPRSANLTRHLRT 332
            ||       ||::....:|.     ...||.|.:   ::..|.|  :.|.:.|.||..||||:|.
Human   302 QDLKALNTSYQSQLIKPSRM-----RKYPNRPSKTPPHERPYACPVESCDRRFSRSDELTRHIRI 361

  Fly   333 HTGEQPYKCKYCERSFSISSNLQRHVRNIHNKERPFKCEICERCFGQQTNLDRHLKKH------- 390
            |||::|::|:.|.|:||.|.:|..|:|. |..|:||.|:||.|.|.:.....||.|.|
Human   362 HTGQKPFQCRICMRNFSRSDHLTTHIRT-HTGEKPFACDICGRKFARSDERKRHTKIHLRQKDKK 425

  Fly   391 -ESDAVSLSALSGVSERMHCIRRFCENPTEESY-FEEIRSFMGKVTQQQQQQQQQQQHDQQQQQH 453
             :...|:.||.|.:|.....:.....:|...|| .....|:...|
Human   426 ADKSVVASSATSSLSSYPSPVATSYPSPVTTSYPSPATTSYPSPV-------------------- 470

  Fly   454 QSTATSASSSCSSSRDTPTSSHEEADHAPATSTADTAAPSSSRDQEEEDSQPIMELKRTLTSKLF 518
               .||.||..||:..:|..|   ...:|:.:|..::.|.:...|       :.....:..:..|
Human   471 ---PTSFSSPGSSTYPSPVHS---GFPSPSVATTYSSVPPAFPAQ-------VSSFPSSAVTNSF 522

  Fly   519 PTTTADSAMT---TPQTTSI 535
            ..:|..|.||   :|:|..|
Human   523 SASTGLSDMTATFSPRTIEI 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	27/67 (40%)
		zf-C2H2	311..333	CDD:278523	11/23 (48%)
		C2H2 Zn finger	313..333	CDD:275368	10/21 (48%)
		zf-H2C2_2	325..349	CDD:290200	12/23 (52%)
		C2H2 Zn finger	341..362	CDD:275368	9/20 (45%)
		zf-H2C2_2	353..377	CDD:290200	11/23 (48%)
		zf-C2H2	368..390	CDD:278523	9/21 (43%)
		C2H2 Zn finger	370..390	CDD:275368	8/19 (42%)
EGR1	NP_001955.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..105		14/54 (26%)
		DUF3446	135..209	CDD:314753	13/81 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	165..213		15/55 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	264..284		3/19 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	318..339		4/25 (16%)
		zf-C2H2	338..362	CDD:306579	11/23 (48%)
		C2H2 Zn finger	340..362	CDD:275368	10/21 (48%)
		zf-H2C2_2	354..379	CDD:316026	13/24 (54%)
		C2H2 Zn finger	370..390	CDD:275368	9/20 (45%)
		zf-H2C2_2	382..407	CDD:316026	12/25 (48%)
		C2H2 Zn finger	398..418	CDD:275368	8/19 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	409..487		21/100 (21%)
		DUF3432	447..530	CDD:288743	19/115 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910