DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and let-391

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_491744.3	Gene:	let-391 / 182953	WormBaseID:	WBGene00006492	Length:	453	Species:	Caenorhabditis elegans

Alignment Length:	402	Identity:	85/402 - (21%)
Similarity:	145/402 - (36%)	Gaps:	130/402 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 NHIAAS-LADLGF-----------DMSRKMLRALREGGAGGGGGGGGGGGGGGGPPNAPPLTPPQ 191
            ||.... :.||.|           :.||:....|...|....|            |..|.|.|.:
Worm   102 NHFRVQHMGDLPFLCNFGCGKRFVNNSRRTAHELSHNGLKRAG------------PARPYLKPVK 154

  Fly   192 CSIPAVHPTL-LEAMTKNLPLQYRNVFAGVLPGKVNS------PAASSSPT----------GADF 239
               ..|.|:: ::.::.:....|      :.|..::|      ..:||||:          .:.:
Worm   155 ---KIVCPSMDMDILSNSALANY------ISPPTIDSIFQSDPSTSSSSPSQFQSSNQTTKQSIY 210

  Fly   240 PFRHPLKKCELT---------------WPPPTEQLQLELPHPNPKLSPVLPHPQLQDYQTRRKNK 289
            |....::|..::               ..|..|::.:|.|.         ..||.:.|.:.|:
Worm   211 PSEKEMEKAAISNARIDDVINTVLARVLAPIDEEIPIEEPE---------KAPQKRAYISNRR-- 264

  Fly   290 ARTAATGGNATPNLPQRNKDRYTCKFCGKVFPRSANLTRHLRTHTGEQPYKCKYCERSFSISSNL 354
                     ||  |.|       |..||.:....:.:..|:||||||:|::|..|..|.|.:|:|
Worm   265 ---------AT--LAQ-------CNICGLMLKHPSKIADHIRTHTGEKPFECGECGLSLSKASSL 311

  Fly   355 QRHVRNIHNKERPFKCEICERCFGQQTNLDRHLKKHESDAVSLSALSGVSERMHCIRRFC----- 414
            :.|:|.:|..||||:|  ..|| |.....|...|:||     ::..:|: :|..|:.:.|
Worm   312 KVHIRRMHTGERPFEC--TWRC-GLSFVTDSVRKEHE-----MTVHTGI-KRYTCVVKGCNAVFA 367

  Fly   415 ---------ENPTEESY---FEEIRSFMGKVTQQQQQQQQQQQHDQQQQQHQSTATSASSSCSSS 467
                     :|...|.:   |:.:     :|..::.|.......|..:|.:|....:....
Worm   368 RRVYLMRHRKNAHPELFTPIFDHV-----QVNHEESQDSVIVYEDDHEQNNQIIMLTGDGD---- 423

  Fly   468 RDTPTSSHEEAD 479
             |....:|.|.|
Worm   424 -DVKILAHFEDD 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	22/62 (35%)
		zf-C2H2	311..333	CDD:278523	5/21 (24%)
		C2H2 Zn finger	313..333	CDD:275368	5/19 (26%)
		zf-H2C2_2	325..349	CDD:290200	11/23 (48%)
		C2H2 Zn finger	341..362	CDD:275368	8/20 (40%)
		zf-H2C2_2	353..377	CDD:290200	10/23 (43%)
		zf-C2H2	368..390	CDD:278523	7/21 (33%)
		C2H2 Zn finger	370..390	CDD:275368	6/19 (32%)
let-391	NP_491744.3	C2H2 Zn finger	59..79	CDD:275368
		zf-H2C2_2	73..96	CDD:290200
		C2H2 Zn finger	87..108	CDD:275368	2/5 (40%)
		C2H2 Zn finger	116..137	CDD:275368	3/20 (15%)
		C2H2 Zn finger	270..290	CDD:275368	5/19 (26%)
		zf-H2C2_2	286..304	CDD:290200	10/17 (59%)
		C2H2 Zn finger	298..319	CDD:275368	8/20 (40%)
		C2H2 Zn finger	327..347	CDD:275368	8/27 (30%)
		C2H2 Zn finger	357..377	CDD:275368	2/19 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910