DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10348 and ZNF784

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_976308.1	Gene:	ZNF784 / 147808	HGNCID:	33111	Length:	323	Species:	Homo sapiens

Alignment Length:	326	Identity:	84/326 - (25%)
Similarity:	123/326 - (37%)	Gaps:	92/326 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 SSFDQPLDLRLA------HKRKTDLVDQGPMEDENSNLIMFASELAVAQQKEKELNNNHIAASLA 146
            |...:||||.|.      ....:||::...::..::.|:          .:..|..:.|.|  |.
Human    18 SRSQEPLDLVLVPDDCRPGTPPSDLIEIQVVKVTDTTLV----------PEPPEPGSFHCA--LC 70

  Fly   147 DLGFDMSRKMLRALREGGAGGGGGGGGGGGG-------GGGPPNAPPL----------TPPQCSI 194
            ...|.:..::|  ..|.|...|..|||.||.       |...|....|          .|.:|
Human    71 PAAFRLVSELL--FHEHGHLAGAEGGGQGGDPSRCHVCGHSCPGPASLRAHYSLHTGERPYRC-- 131

  Fly   195 PAVHPTLLEAMTKNLPLQYRNVFAGVLPGKVNSPAASSSPTGADFPFRHPLKKCELTWPPPTEQL 259
             |:.|...:|:...|..|:|:   ||.||....                         ||.|..:
Human   132 -ALCPRAFKALAPLLRHQHRH---GVEPGTSRR-------------------------PPDTAAV 167

  Fly   260 QLELPHPNPKLSPVLPHPQLQDYQTRRKNKARTAATGGNATPNLPQRNKDRYTCKFCGKVFPRSA 324
            ..:.|...|:.:.|:                 .||....|....|      :.|:||.|.|.||:
Human   168 AEQRPGVAPERAEVV-----------------MAAAAAGAAVGKP------FACRFCAKPFRRSS 209

  Fly   325 NLTRHLRTHTGEQPYKCKYCERSFSISSNLQRHVRNIHNKERPFKCEICERCFGQQTNLDRHLKK 389
            ::..|.|.||||:||.|..|.:.|:.||.|..|.| ||..||||:|.:|:|.|...:|..:|.:.
Human   210 DMRDHERVHTGERPYHCGICGKGFTQSSVLSGHAR-IHTGERPFRCTLCDRTFNNSSNFRKHQRT 273

  Fly   390 H 390
            |
Human   274 H 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	25/62 (40%)
		zf-C2H2	311..333	CDD:278523	9/21 (43%)
		C2H2 Zn finger	313..333	CDD:275368	9/19 (47%)
		zf-H2C2_2	325..349	CDD:290200	10/23 (43%)
		C2H2 Zn finger	341..362	CDD:275368	8/20 (40%)
		zf-H2C2_2	353..377	CDD:290200	12/23 (52%)
		zf-C2H2	368..390	CDD:278523	7/21 (33%)
		C2H2 Zn finger	370..390	CDD:275368	6/19 (32%)
ZNF784	NP_976308.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		3/7 (43%)
		C2H2 Zn finger	67..87	CDD:275368	5/23 (22%)
		C2H2 Zn finger	103..123	CDD:275368	3/19 (16%)
		C2H2 Zn finger	131..151	CDD:275368	6/22 (27%)
		COG5048	<194..276	CDD:227381	37/88 (42%)
		C2H2 Zn finger	198..218	CDD:275368	9/19 (47%)
		C2H2 Zn finger	226..246	CDD:275368	8/20 (40%)
		C2H2 Zn finger	254..274	CDD:275368	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	269..323		2/6 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24393
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100