DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and Mecom

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001347963.1	Gene:	Mecom / 14013	MGIID:	95457	Length:	1242	Species:	Mus musculus

Alignment Length:	722	Identity:	187/722 - (25%)
Similarity:	280/722 - (38%)	Gaps:	217/722 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GCVYPAL--------GLIPTSYISHVPYDLASSASVAATSSSSTSPTTTSATTTGRLQHQHSHQQ 74
            |..:|..        ||.| |.:.|.|..:.:|..|...||:..|....|...|        |.|
Mouse   481 GLTFPTAPGFSFSFPGLFP-SGLYHRPPLIPASPPVKGLSSTEQSNKCQSPLLT--------HPQ 536

  Fly    75 --------HQTLNHH---AKGK------RRSSFDQPLDLRLAHKRKTDLVD-------------- 108
                    .:.|:.|   ...|      .|||.::||:........:||.|
Mouse   537 ILPATQDILKALSKHPPVGDNKPVELLPERSSEERPLEKISDQSESSDLDDVSTPSGSDLETTSG 601

  Fly   109 ---QGPMEDE----NSNLIMFASELA----VAQQKEKELNNNH--IAASLADL-----GFDMSRK 155
               :..:|.:    ..|..||..:::    :|....|:.:|||  .:||:.:.     ..:.|.|
Mouse   602 SDLESDLESDKEKCKENGKMFKDKVSPLQNLASITNKKEHNNHSVFSASVEEQSAVSGAVNDSIK 666

  Fly   156 MLRALREGGAGGGGGGGGGGGGGGGPPNAPPLTPPQCSIPAVHPTLLEAM-------TKNLPL-- 211
            .:.::.|...|..|..|......|..| .|.:.|    :| ..|...::|       .::|||
Mouse   667 AIASIAEKYFGSTGLVGLQDKKVGALP-YPSMFP----LP-FFPAFSQSMYPFPDRDLRSLPLKM 725

  Fly   212 --QYRNVFAGVLPGKVNSP--------------AASSSPTGA-----DFP--------------- 240
              |..:....:..|...||              :..|.|:|.     |.|
Mouse   726 EPQSPSEVKKLQKGSSESPFDLTTKRKDEKPLTSGPSKPSGTPATSQDQPLDLSMGSRGRASGTK 790

  Fly   241 ------------------------------------FRHPL---KKCELTWPPPTEQLQLELPHP 266
                                                |..|:   :|.:||  .|.|.|:.:...|
Mouse   791 LTEPRKNHVFGEKKGSNMDTRPSSDGSLQHARPTPFFMDPIYRVEKRKLT--DPLEALKEKYLRP 853

  Fly   267 NP--KLSPVLPHPQLQDYQTRRKNKARTAATGGNATP------------------------NLPQ 305
            :|  ...|..|.|..:.:.:..:|.|....:.....|                        ||.:
Mouse   854 SPGFLFHPQFPLPDQRTWMSAIENMAEKLESFSALKPEASELLQSVPSMFSFRAPPNTLPENLLR 918

  Fly   306 RNKDRYTCKFCGKVFPRSANLTRHLRTHTGEQPYKCKYCERSFSISSNLQRHVRNIHNKERPFKC 370
            :.|:||||::|||:||||||||||||||||||||:||||:||||||||||||||||||||:||||
Mouse   919 KGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKC 983

  Fly   371 EICERCFGQQTNLDRHLKKHESDAVSLSALSGVSERMHCIRRFCENPTEESYFEEIRSFMGKVT- 434
            .:|:|||||||||||||||||:..:|.:|.|.....:.......:: .|::||.|||:|:|...
Mouse   984 HLCDRCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESAGAILDD-KEDAYFTEIRNFIGNSNH 1047

  Fly   435 -QQQQQQQQQQQHDQQQQQHQSTATSASSSC---------------SSSRDTPTSSHEEA----- 478
             .|..:..:::.:....:..::.|||.:|..               ....|.|....:|.
Mouse  1048 GSQSPRNMEERMNGSHFKDKKALATSQNSDLLDDEEVEDEVLLDEEDEDNDIPGKPRKELGVTRL 1112

  Fly   479 ---------DHAPATSTADTAAPSSSRDQEEEDSQPIMELKRTLTSKLFPTTTADSAMTTPQTTS 534
                     :.|.|...:..|:|...::::.:.....::..|..|..|......::..|..:.:|
Mouse  1113 DEEIPEDDYEEAGALEMSCKASPVRYKEEDYKSGLSALDHIRHFTDSLKMREMEENQYTDAELSS 1177

  Fly   535 I-KEEVP 540
            | ...||
Mouse  1178 ISSSHVP 1184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	51/86 (59%)
		zf-C2H2	311..333	CDD:278523	18/21 (86%)
		C2H2 Zn finger	313..333	CDD:275368	16/19 (84%)
		zf-H2C2_2	325..349	CDD:290200	21/23 (91%)
		C2H2 Zn finger	341..362	CDD:275368	19/20 (95%)
		zf-H2C2_2	353..377	CDD:290200	19/23 (83%)
		zf-C2H2	368..390	CDD:278523	18/21 (86%)
		C2H2 Zn finger	370..390	CDD:275368	16/19 (84%)
Mecom	NP_001347963.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..68
		SET	90..194	CDD:214614
		C2H2 Zn finger	213..262	CDD:275368
		C2H2 Zn finger	267..287	CDD:275368
		zf-H2C2_2	279..303	CDD:316026
		C2H2 Zn finger	295..315	CDD:275368
		C2H2 Zn finger	323..345	CDD:275368
		C2H2 Zn finger	353..373	CDD:275368
		zf-C2H2_8	354..438	CDD:318181
		C2H2 Zn finger	381..401	CDD:275368
		C2H2 Zn finger	410..428	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..623		13/73 (18%)
		Nuclear localization signal. /evidence=ECO:0000255	612..625		3/12 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	721..824		12/102 (12%)
		CTBP-binding motif 1. /evidence=ECO:0000250	744..748		1/3 (33%)
		CTBP-binding motif 2. /evidence=ECO:0000250	775..779		1/3 (33%)
		PHA00733	880..976	CDD:177301	51/95 (54%)
		zf-C2H2	924..946	CDD:306579	18/21 (86%)
		C2H2 Zn finger	926..946	CDD:275368	16/19 (84%)
		zf-H2C2_2	938..962	CDD:316026	21/23 (91%)
		C2H2 Zn finger	954..975	CDD:275368	19/20 (95%)
		zf-H2C2_2	966..992	CDD:316026	21/25 (84%)
		C2H2 Zn finger	983..1003	CDD:275368	16/19 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1042..1117		9/74 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849081
Domainoid	1	1.000	54	1.000	Domainoid score	I11201
eggNOG	1	0.900	-	-		E33208_3BAJ6
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002720
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24393
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4026
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.920