DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and KLF6

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001291.3	Gene:	KLF6 / 1316	HGNCID:	2235	Length:	283	Species:	Homo sapiens

Alignment Length:	180	Identity:	61/180 - (33%)
Similarity:	87/180 - (48%)	Gaps:	33/180 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 SPAA--SSSPTGADFPFRHPLKKCELTWPPPTEQLQLELPHPNPKLSPV---LPHPQLQDYQTRR 286
            ||.|  :|.|.|........|.....:.||.:.:|..|   |:.....|   ||.|
Human   120 SPTAKFTSDPIGEVLVSSGKLSSSVTSTPPSSPELSRE---PSQLWGCVPGELPSP--------- 172

  Fly   287 KNKARTAATG-------GNATPNLPQRNKDRYTCKF--CGKVFPRSANLTRHLRTHTGEQPYKCK 342
             .|.|:..:|       |:|:|:..:|   .:.|.|  |.||:.:|::|..|.||||||:||:|.
Human   173 -GKVRSGTSGKPGDKGNGDASPDGRRR---VHRCHFNGCRKVYTKSSHLKAHQRTHTGEKPYRCS 233

  Fly   343 Y--CERSFSISSNLQRHVRNIHNKERPFKCEICERCFGQQTNLDRHLKKH 390
            :  ||..|:.|..|.||.|. |...:||||..|:|||.:..:|..|:|:|
Human   234 WEGCEWRFARSDELTRHFRK-HTGAKPFKCSHCDRCFSRSDHLALHMKRH 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	27/66 (41%)
		zf-C2H2	311..333	CDD:278523	9/23 (39%)
		C2H2 Zn finger	313..333	CDD:275368	9/21 (43%)
		zf-H2C2_2	325..349	CDD:290200	13/25 (52%)
		C2H2 Zn finger	341..362	CDD:275368	9/22 (41%)
		zf-H2C2_2	353..377	CDD:290200	11/23 (48%)
		zf-C2H2	368..390	CDD:278523	10/21 (48%)
		C2H2 Zn finger	370..390	CDD:275368	8/19 (42%)
KLF6	NP_001291.3	9aaTAD, inactive. /evidence=ECO:0000269\|PubMed:31375868	62..70
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	106..198		22/90 (24%)
		COG5048	177..>265	CDD:227381	35/91 (38%)
		C2H2 Zn finger	205..224	CDD:275368	7/18 (39%)
		C2H2 Zn finger	232..254	CDD:275368	9/22 (41%)
		zf-C2H2	260..282	CDD:333835	10/21 (48%)
		C2H2 Zn finger	262..282	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910