DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and AgaP_AGAP002083

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_320962.5	Gene:	AgaP_AGAP002083 / 1281033	VectorBaseID:	AGAP002083	Length:	994	Species:	Anopheles gambiae

Alignment Length:	568	Identity:	127/568 - (22%)
Similarity:	205/568 - (36%)	Gaps:	195/568 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PYDLASSASVAATSSSSTSPTTTSATTT-----------GRLQHQHSHQ-----------QHQTL 78
            |...::.:|:||...::...::|:||.|           |.:|.|:..|           :|.|.
Mosquito   313 PQSPSAGSSLAANEGATPDSSSTTATATAIPNFNQMPVPGGVQGQNPTQGLVHWMSAVMAEHMTS 377

  Fly    79 N-HH---AKG---------KRRSSFD---------QPLDLRLAHKRKTDLVD------------- 108
            | ||   |.|         :.....|         .|:.::..::.|.:.||
Mosquito   378 NPHHDPAAVGMHYMWNGPVEHTKDMDTYGGWPAPRNPMSMKQGYEAKMNPVDHHHHHHHHHHNNL 442

  Fly   109 -QGPMEDENSNLIMFASELAVAQQKEKELNNNHIAASLADLGFDMSRKMLRALREGGAGGGGGGG 172
             :|.|.|:...|.....:...||..:                       |...| |.:.....||
Mosquito   443 QKGHMIDDGRLLDHHTMQTGAAQMSQ-----------------------LYGAR-GSSSSSSPGG 483

  Fly   173 GGGGGGGGPPNAPPLTPPQCSIPAVHPTLLEAMTKNLPLQYRNVFAGVLPGKVNSP--AASSSPT 235
            |.|..||||.|           ||.  .||                 |:|..:|:.  .|:..|.
Mosquito   484 GLGHAGGGPTN-----------PAA--ALL-----------------VVPQPINATKIGATGLPN 518

  Fly   236 GADFPFRHPLKKCELTWPPPTEQLQLELPHPNPKLSPVLPHPQL-----QDYQTRRKNKARTAAT 295
            |..  .::..|.|...:   |.:..|:|            |.|:     :.|:..:.|||...::
Mosquito   519 GTG--RKYQCKMCPQIF---TSKADLQL------------HTQIHMREAKPYKCSQCNKAFANSS 566

  Fly   296 GGNATPNLPQRNK-----DRYTCKFCGKVFPRSANLTRHLRTHTGEQPYKCKY--CERSFSISSN 353
                  .|.|..:     ..|.|:.|.:.|.:.::|.:|:|||||::||||::  |.::||..||
Mosquito   567 ------YLSQHTRIHLGIKPYRCEICQRKFTQLSHLQQHIRTHTGDKPYKCRHSGCLKAFSQLSN 625

  Fly   354 LQRHVRNIHNKERPFKCEICERCFGQQTNLDRHLKKHESDAVSLSALSGVSERMHCIRRFCENPT 418
            ||.|.| .|..::|:||..|.:||..:..|..|:.||:             |..|.....|:
Mosquito   626 LQSHSR-CHQTDKPYKCNSCYKCFADEPALLEHIPKHK-------------ESKHLKTHICQ--- 673

  Fly   419 EESYFEEIRSFMGK-VTQQQQQQQQQQQHDQQQQQHQSTAT-SASSSCSSSRDTPTSSHEEADHA 481
                      :.|| .||:....:..|:|.::..:.....| |:||:.:.|..||.||......:
Mosquito   674 ----------YCGKSYTQETYLSKHMQKHAERTDKRPPIGTRSSSSTVNLSASTPGSSSSSGSAS 728

  Fly   482 PATSTADTAAPSSSRDQEEEDSQPIMELKRTLTSKLFPTTTADSAMTT 529
            ...::...||.|.:.:                 |..:|..:.|||..|
Mosquito   729 NGATSNGGAATSMAGE-----------------SAFWPKVSPDSAAAT 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	26/69 (38%)
		zf-C2H2	311..333	CDD:278523	7/21 (33%)
		C2H2 Zn finger	313..333	CDD:275368	6/19 (32%)
		zf-H2C2_2	325..349	CDD:290200	12/25 (48%)
		C2H2 Zn finger	341..362	CDD:275368	10/22 (45%)
		zf-H2C2_2	353..377	CDD:290200	10/23 (43%)
		zf-C2H2	368..390	CDD:278523	7/21 (33%)
		C2H2 Zn finger	370..390	CDD:275368	6/19 (32%)
AgaP_AGAP002083	XP_320962.5	C2H2 Zn finger	526..546	CDD:275368	7/34 (21%)
		zf-H2C2_2	538..564	CDD:290200	8/37 (22%)
		zf-C2H2	553..575	CDD:278523	6/27 (22%)
		C2H2 Zn finger	555..575	CDD:275368	5/25 (20%)
		zf-H2C2_2	567..592	CDD:290200	6/24 (25%)
		zf-C2H2	581..603	CDD:278523	7/21 (33%)
		C2H2 Zn finger	583..603	CDD:275368	6/19 (32%)
		zf-C2H2_8	586..666	CDD:292531	34/93 (37%)
		zf-H2C2_2	595..622	CDD:290200	13/26 (50%)
		C2H2 Zn finger	611..633	CDD:275368	10/22 (45%)
		zf-H2C2_2	625..649	CDD:290200	11/24 (46%)
		C2H2 Zn finger	641..670	CDD:275368	10/41 (24%)
		zf-C2H2	670..692	CDD:278523	6/34 (18%)
		C2H2 Zn finger	672..692	CDD:275371	6/32 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910