DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and AgaP_AGAP008901

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_319648.4	Gene:	AgaP_AGAP008901 / 1279868	VectorBaseID:	AGAP008901	Length:	675	Species:	Anopheles gambiae

Alignment Length:	344	Identity:	84/344 - (24%)
Similarity:	132/344 - (38%)	Gaps:	82/344 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 GGGGGGGGGGPPNAPPL------TPPQCSIPAVHPTLLEAMTKNLPLQYRNVFAGVLPGKVNSPA 229
            |..|..|..|....|||      ..|..:.|.|...|.:...::|| .:.|...   |.:.::|:
Mosquito    74 GTAGSYGEPGDVEKPPLFYRKAFDMPYMATPYVQSHLAQQFPQHLP-SHPNQLP---PHQHHAPS 134

  Fly   230 ASSSPTGADFPFRHPLKK-----------CELTWPPPTEQLQLELPHPNPKLSPVLPHPQLQDYQ 283
            .:.||..|.:|...|:..           ||   ||.:.:::.:. ...||           .:.
Mosquito   135 ETGSPLPASYPTASPVAPPAATPSPYTPLCE---PPDSSKVRFKC-ETCPK-----------SFD 184

  Fly   284 TRRK----NKARTAATGGNATPNLPQRNKDR-----------------------YTCKFCGKVFP 321
            |::|    |:......||.|......|..|:                       .:|..|||||.
Mosquito   185 TKQKLEKHNRIHQPNGGGAAGLEFKCRMCDKTFRTKSTLICHEKVHGESGLGSSCSCVECGKVFA 249

  Fly   322 RSANLTRHLRTHTGEQPYKCKYCERSFSISSNLQRHVRNIHNK-ERPFKCEICERCFGQQTNLDR 385
            ....|..|.|.||||:||:||.|.:.|:..|||..|.| ||:| ::..||..|.:....:..|..
Mosquito   250 TEEKLQVHRRLHTGEKPYQCKVCLKCFNHQSNLIVHAR-IHDKVKQALKCARCSKVLDSEERLAV 313

  Fly   386 HLKKHESDAVSLSALSGVSERMHCIRRFCENPT----EESYFEEIRSF-MGKVTQQQQQQQQQQQ 445
            |::.|..:.....:        :|.:||....|    |::......|: .|:..:...|:.|.|.
Mosquito   314 HMRLHTGEKPYKCS--------YCDKRFNHKSTVSTHEKAAHIAANSYRCGRCHKTFNQKCQLQY 370

  Fly   446 HDQQQQQHQSTATSASSSC 464
            |::.|::|    |.|...|
Mosquito   371 HEKLQEEH----TIACEHC 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	27/85 (32%)
		zf-C2H2	311..333	CDD:278523	9/21 (43%)
		C2H2 Zn finger	313..333	CDD:275368	9/19 (47%)
		zf-H2C2_2	325..349	CDD:290200	12/23 (52%)
		C2H2 Zn finger	341..362	CDD:275368	9/20 (45%)
		zf-H2C2_2	353..377	CDD:290200	10/24 (42%)
		zf-C2H2	368..390	CDD:278523	5/21 (24%)
		C2H2 Zn finger	370..390	CDD:275368	4/19 (21%)
AgaP_AGAP008901	XP_319648.4	C2H2 Zn finger	176..196	CDD:275368	5/31 (16%)
		C2H2 Zn finger	210..230	CDD:275368	2/19 (11%)
		C2H2 Zn finger	241..261	CDD:275368	9/19 (47%)
		zf-H2C2_2	254..278	CDD:290200	13/23 (57%)
		C2H2 Zn finger	269..289	CDD:275368	9/20 (45%)
		C2H2 Zn finger	298..318	CDD:275368	4/19 (21%)
		zf-H2C2_2	311..335	CDD:290200	6/31 (19%)
		DUF45	<324..365	CDD:302795	7/48 (15%)
		C2H2 Zn finger	326..347	CDD:275368	5/28 (18%)
		C2H2 Zn finger	355..374	CDD:275368	5/18 (28%)
		C2H2 Zn finger	382..403	CDD:275368	1/4 (25%)
		C2H2 Zn finger	427..447	CDD:275368
		C2H2 Zn finger	460..480	CDD:275368
		C2H2 Zn finger	564..584	CDD:275368
		C2H2 Zn finger	592..612	CDD:275368
		C2H2 Zn finger	622..642	CDD:275368
		C2H2 Zn finger	650..668	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910