DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and AgaP_AGAP010926

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_309767.4	Gene:	AgaP_AGAP010926 / 1271025	VectorBaseID:	AGAP010926	Length:	443	Species:	Anopheles gambiae

Alignment Length:	403	Identity:	90/403 - (22%)
Similarity:	136/403 - (33%)	Gaps:	143/403 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 QHQHSHQQHQTLNHHAKGKRRSSFDQPLDLRLAHKRKTDLVDQGPMEDENSNLIMFASELAVAQQ 131
            ||.|.|..|    ||          ||      |                             |.
Mosquito   175 QHHHHHHHH----HH----------QP------H-----------------------------QH 190

  Fly   132 KEKELNNNHIAASLADLGFDMSRKMLRALREGGA---GGGGGGGGGGGGGGGPPNAPPLTPPQCS 193
            :|::               |..|:..|.|.|..:   .|...||||........|       ...
Mosquito   191 QERQ---------------DRQRETARILTEYNSLLLNGRQSGGGGSRSSQDYFN-------YSK 233

  Fly   194 IPAVHPTLLEAMTKNLPLQYRN-----VFAGVLPGKVNSPAASSSPTGADFPFRHPLKKCELTWP 253
            |...:.|.|:...|||.:..:|     |..|...........:.:.||.:   |......:..|
Mosquito   234 ISKGYFTHLQQQQKNLEILRQNRTDLFVLNGGNDNNNKEGVKNQNQTGHE---RSGGAGSKQNW- 294

  Fly   254 PPTEQLQLELPHPNPKLSPVLPHPQLQDYQTRRKNKARTAATGGNATPNLPQRNKDRYTCKFCGK 318
               ::....:.||..:..|      ..|:.:..|.|             :|.|   .:.||.|||
Mosquito   295 ---DRKLFGISHPVERKIP------FDDHASPPKKK-------------MPGR---LHQCKQCGK 334

  Fly   319 VFPRSANLTRHLRTHTGEQPYKCKYCERSFSISSNLQRHVRNIHNKERPFKCEICERCFGQQTNL 383
            .|.||:.|:.||..|:..:||.|:||.:.|...|::::|. .||..|:|.||.:|.:.|.|.:||
Mosquito   335 TFKRSSTLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHT-YIHTGEKPHKCVVCLKAFSQSSNL 398

  Fly   384 DRHLKKHESDAVSLSALSGVSERMHCIRRFCENPTEESYFEEIRSFMGKVTQQQQQQQQQQQHDQ 448
            ..|::||          ||. :...|  ..|:           ::|..||..::          .
Mosquito   399 ITHMRKH----------SGY-KPFSC--GLCD-----------KAFQRKVDLRR----------H 429

  Fly   449 QQQQHQSTATSAS 461
            ::.||...||:.|
Mosquito   430 REGQHNEPATAGS 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	23/62 (37%)
		zf-C2H2	311..333	CDD:278523	11/21 (52%)
		C2H2 Zn finger	313..333	CDD:275368	11/19 (58%)
		zf-H2C2_2	325..349	CDD:290200	9/23 (39%)
		C2H2 Zn finger	341..362	CDD:275368	6/20 (30%)
		zf-H2C2_2	353..377	CDD:290200	8/23 (35%)
		zf-C2H2	368..390	CDD:278523	8/21 (38%)
		C2H2 Zn finger	370..390	CDD:275368	7/19 (37%)
AgaP_AGAP010926	XP_309767.4	zf-C2H2	327..349	CDD:278523	11/21 (52%)
		C2H2 Zn finger	329..349	CDD:275368	11/19 (58%)
		COG5048	337..>413	CDD:227381	30/87 (34%)
		zf-H2C2_2	342..366	CDD:290200	10/23 (43%)
		C2H2 Zn finger	357..377	CDD:275368	6/20 (30%)
		zf-H2C2_2	369..394	CDD:290200	9/25 (36%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		zf-H2C2_2	397..420	CDD:290200	9/46 (20%)
		C2H2 Zn finger	413..430	CDD:275368	5/39 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910