DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and klf3

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_571934.3	Gene:	klf3 / 117603	ZFINID:	ZDB-GENE-011116-1	Length:	328	Species:	Danio rerio

Alignment Length:	410	Identity:	101/410 - (24%)
Similarity:	148/410 - (36%)	Gaps:	122/410 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PSPKQGCVYPALGLIPTSYISHVPYDLASSASVAATSSSSTSPTTTSATTTGRLQHQH------- 70
            |.|......|...||.    ||..:.:....:|  .|.:...|:           |.|
Zfish     6 PKPDMSLYQPYSTLIK----SHETFGMVLPPAV--VSGAHLYPS-----------HYHPSYQLPY 53

  Fly    71 SHQQHQTLNHHAKGKRRSSFDQPLDLRLAHKRKTDLVDQGPMEDENSNLIMFASELAVAQQKEKE 135
            ||:|.|.: |.|:       .:|:||.:.:|..    ...|           :|.||.:..:...
Zfish    54 SHRQSQDV-HQAQ-------IEPVDLSIGNKSS----GSSP-----------SSSLASSSPRASP 95

  Fly   136 LN--NNHIAASLADLGFDMSRKMLRALREGGAGGGGGGGGGGGGGGGPPNAPPLTPPQCSIPAVH 198
            .:  ..|..||.......:|                               |.||.|   ||||.
Zfish    96 PSPYEAHSPASRCSQNRQLS-------------------------------PSLTLP---IPAVT 126

  Fly   199 PTLL-----EAMTKNLPLQYRNVFAGVLPGKVNSPAASSSPTGADFPFRH---PLKKCELTWPPP 255
            ..|.     ..|...:|:....::.   |....||:...||...:.|..|   .:.|.|.|
Zfish   127 QVLTPFVSSPGMIPVIPMPLSVLYP---PSLHLSPSIIISPVTPEDPANHKHFSVIKSENT---- 184

  Fly   256 TEQLQLELPHPNPKLSPVL--PHPQ-LQDYQTRRKNKARTAAT----GGNATPNL--PQRNKDR- 310
            ::..:|        |.|:.  |||: .||..::.|:.......    |...:|.:  |...|.|
Zfish   185 SDHHEL--------LKPIKSEPHPEHTQDNHSQEKSVITALPNYNDRGNTQSPKVESPDLLKKRR 241

  Fly   311 -YTCKF--CGKVFPRSANLTRHLRTHTGEQPYKCKY--CERSFSISSNLQRHVRNIHNKERPFKC 370
             :.|.|  |.||:.:|::|..|.||||||:||||.:  |...|:.|..|.||.|. |...:||.|
Zfish   242 IHRCDFNGCNKVYTKSSHLKAHRRTHTGEKPYKCMWEGCTWKFARSDELTRHYRK-HTGVKPFHC 305

  Fly   371 EICERCFGQQTNLDRHLKKH 390
            ..|:|.|.:..:|..|.|:|
Zfish   306 PDCDRTFSRSDHLALHKKRH 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	29/70 (41%)
		zf-C2H2	311..333	CDD:278523	9/23 (39%)
		C2H2 Zn finger	313..333	CDD:275368	9/21 (43%)
		zf-H2C2_2	325..349	CDD:290200	13/25 (52%)
		C2H2 Zn finger	341..362	CDD:275368	8/22 (36%)
		zf-H2C2_2	353..377	CDD:290200	10/23 (43%)
		zf-C2H2	368..390	CDD:278523	8/21 (38%)
		C2H2 Zn finger	370..390	CDD:275368	7/19 (37%)
klf3	NP_571934.3	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910