DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and KLF8

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001311033.1	Gene:	KLF8 / 11279	HGNCID:	6351	Length:	364	Species:	Homo sapiens

Alignment Length:	319	Identity:	80/319 - (25%)
Similarity:	128/319 - (40%)	Gaps:	63/319 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 QPLDLRLAHKRKTDL----VDQGPM-----EDENSNLIM--FASELAVAQQKEKELNNNHIAASL 145
            :|:||.. ||.|..|    :.|.|:     :.....|::  ..|:::.:......|....:..|.
Human    90 EPVDLSF-HKPKAPLQPASMLQAPIRPPKPQSSPQTLVVSTSTSDMSTSANIPTVLTPGSVLTSS 153

  Fly   146 ADLGFDMSRKMLRALREGGAGGGGGGGGGGGGGGGPPNAPPLTPPQCSIPAVHPTL--LEAMTKN 208
            ...|   |:::|..:.                          |.|..|:|.....|  :..:.::
Human   154 QSTG---SQQILHVIH--------------------------TIPSVSLPNKMGGLKTIPVVVQS 189

  Fly   209 LPLQYRNVFAGVLPGKVNSPAASSSP-TGADFPFRHPLKKCELTWPPPTEQLQLELPHPNPKLSP 272
            ||:.|.     .||.. ..|||.:.| .|.|.      |........||....||:|..:.:.:.
Human   190 LPMVYT-----TLPAD-GGPAAITVPLIGGDG------KNAGSVKVDPTSMSPLEIPSDSEESTI 242

  Fly   273 VLPHPQLQDYQTRRKNKARTAATGGNATPNLPQRNKDRYTCKF--CGKVFPRSANLTRHLRTHTG 335
            ......||..|..::..|..|...|..:.:|.:|.  .:.|.|  |.||:.:|::|..|.|.|||
Human   243 ESGSSALQSLQGLQQEPAAMAQMQGEESLDLKRRR--IHQCDFAGCSKVYTKSSHLKAHRRIHTG 305

  Fly   336 EQPYKCKY--CERSFSISSNLQRHVRNIHNKERPFKCEICERCFGQQTNLDRHLKKHES 392
            |:||||.:  |...|:.|..|.||.|. |...:||:|..|.|.|.:..:|..|.::|::
Human   306 EKPYKCTWDGCSWKFARSDELTRHFRK-HTGIKPFRCTDCNRSFSRSDHLSLHRRRHDT 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	26/66 (39%)
		zf-C2H2	311..333	CDD:278523	9/23 (39%)
		C2H2 Zn finger	313..333	CDD:275368	9/21 (43%)
		zf-H2C2_2	325..349	CDD:290200	12/25 (48%)
		C2H2 Zn finger	341..362	CDD:275368	8/22 (36%)
		zf-H2C2_2	353..377	CDD:290200	10/23 (43%)
		zf-C2H2	368..390	CDD:278523	7/21 (33%)
		C2H2 Zn finger	370..390	CDD:275368	6/19 (32%)
KLF8	NP_001311033.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910