DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and PRDM4

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_005268650.1	Gene:	PRDM4 / 11108	HGNCID:	9348	Length:	808	Species:	Homo sapiens

Alignment Length:	223	Identity:	56/223 - (25%)
Similarity:	91/223 - (40%)	Gaps:	29/223 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   266 PNPKLSPVLPHPQLQDYQTRRKNKARTAATGGNATPNL--------PQRNKDRYTCKFCGKVFPR 322
            |...:||...|.....:...:.:|....:...:...||        .|:|   |.|..|.|.|.:
Human   603 PQAFISPSKLHVHFMGHMGMKPHKCDFCSKAFSDPSNLRTHLKIHTGQKN---YRCTLCDKSFTQ 664

  Fly   323 SANLTRHLRTHTGEQPYKCKYCERSFSISSNLQRHVRNIHNKERPFKCEICERCFGQQTNLDRHL 387
            .|:|..|:..||||:..||.||::.|....:|::||. ||.:||..||..|::.|.:..:|.:||
Human   665 KAHLESHMVIHTGEKNLKCDYCDKLFMRRQDLKQHVL-IHTQERQIKCPKCDKLFLRTNHLKKHL 728

  Fly   388 KKHES--DAVSLSALSGVSERMHCIR--RFCENPTEESYFEEIRSFMGKVTQQQQQQQQQQQHDQ 448
            ..||.  |.|..........:.|..|  :.|:.||..|             ...:::::....::
Human   729 NSHEGKRDYVCEKCTKAYLTKYHLTRHLKTCKGPTSSS-------------SAPEEEEEDDSEEE 780

  Fly   449 QQQQHQSTATSASSSCSSSRDTPTSSHE 476
            .......|.....:|...|.|...|:|:
Human   781 DLADSVGTEDCRINSAVYSADESLSAHK 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	25/70 (36%)
		zf-C2H2	311..333	CDD:278523	8/21 (38%)
		C2H2 Zn finger	313..333	CDD:275368	7/19 (37%)
		zf-H2C2_2	325..349	CDD:290200	10/23 (43%)
		C2H2 Zn finger	341..362	CDD:275368	7/20 (35%)
		zf-H2C2_2	353..377	CDD:290200	10/23 (43%)
		zf-C2H2	368..390	CDD:278523	7/21 (33%)
		C2H2 Zn finger	370..390	CDD:275368	6/19 (32%)
PRDM4	XP_005268650.1	SET	433..540	CDD:321994
		C2H2 Zn finger	554..591	CDD:275368
		C2H2 Zn finger	599..619	CDD:275368	4/15 (27%)
		zf-C2H2	625..647	CDD:306579	3/21 (14%)
		C2H2 Zn finger	627..647	CDD:275368	2/19 (11%)
		zf-H2C2_2	639..664	CDD:316026	9/27 (33%)
		C2H2 Zn finger	655..675	CDD:275368	7/19 (37%)
		zf-H2C2_2	667..690	CDD:316026	10/22 (45%)
		C2H2 Zn finger	683..703	CDD:275368	7/20 (35%)
		C2H2 Zn finger	711..731	CDD:275368	6/19 (32%)
		C2H2 Zn finger	739..758	CDD:275368	2/18 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910