DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and ZNF660-ZNF197

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001338661.1	Gene:	ZNF660-ZNF197 / 110354863	-ID:	-	Length:	1029	Species:	Homo sapiens

Alignment Length:	126	Identity:	49/126 - (38%)
Similarity:	64/126 - (50%)	Gaps:	14/126 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 YTCKFCGKVFPRSANLTRHLRTHTGEQPYKCKYCERSFSISSNLQRHVRNIHNKERPFKCEICER 375
            |.|..|||.|.::.||..|.|.||||:||:|..|.:||:...||..|.| ||..|:|:.|..|.:
Human   902 YKCNECGKDFSQNKNLVVHQRMHTGEKPYECDKCRKSFTSKRNLVGHQR-IHTGEKPYGCNDCSK 965

  Fly   376 CFGQQTNLDRHLKKHESDA-----VSLSALSGVS-----ERMHCIRRF--CENPTEESYFE 424
            .|.|:.||..|.|.|..:.     ||....|..|     :::|.|..|  .:| |.||..|
Human   966 VFRQRKNLTVHQKIHTDEKPCECDVSEKEFSQTSNLHLQQKIHTIEEFSWLQN-TNESKIE 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	25/51 (49%)
		zf-C2H2	311..333	CDD:278523	10/21 (48%)
		C2H2 Zn finger	313..333	CDD:275368	9/19 (47%)
		zf-H2C2_2	325..349	CDD:290200	13/23 (57%)
		C2H2 Zn finger	341..362	CDD:275368	8/20 (40%)
		zf-H2C2_2	353..377	CDD:290200	10/23 (43%)
		zf-C2H2	368..390	CDD:278523	8/21 (38%)
		C2H2 Zn finger	370..390	CDD:275368	8/19 (42%)
ZNF660-ZNF197	NP_001338661.1	SCAN	38..150	CDD:128708
		KRAB	216..256	CDD:307490
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..290
		C2H2 Zn finger	372..392	CDD:275368
		zf-H2C2_2	384..409	CDD:316026
		C2H2 Zn finger	400..420	CDD:275368
		COG5048	424..853	CDD:227381
		C2H2 Zn finger	428..448	CDD:275368
		C2H2 Zn finger	456..476	CDD:275368
		C2H2 Zn finger	484..504	CDD:275368
		C2H2 Zn finger	512..532	CDD:275368
		C2H2 Zn finger	540..560	CDD:275368
		C2H2 Zn finger	568..588	CDD:275368
		C2H2 Zn finger	596..616	CDD:275368
		C2H2 Zn finger	624..644	CDD:275368
		C2H2 Zn finger	652..672	CDD:275368
		C2H2 Zn finger	680..700	CDD:275368
		C2H2 Zn finger	708..728	CDD:275368
		C2H2 Zn finger	736..756	CDD:275368
		COG5048	760..>1026	CDD:227381	49/126 (39%)
		C2H2 Zn finger	764..784	CDD:275368
		C2H2 Zn finger	792..812	CDD:275368
		C2H2 Zn finger	820..840	CDD:275368
		C2H2 Zn finger	848..868	CDD:275368
		C2H2 Zn finger	876..896	CDD:275368
		C2H2 Zn finger	904..924	CDD:275368	9/19 (47%)
		C2H2 Zn finger	932..952	CDD:275368	8/20 (40%)
		C2H2 Zn finger	960..980	CDD:275368	8/19 (42%)
		C2H2 Zn finger	988..1008	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910