DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10348 and KLF1

DIOPT Version :9

Sequence 1:NP_001286059.1 Gene:CG10348 / 35132 FlyBaseID:FBgn0032707 Length:540 Species:Drosophila melanogaster
Sequence 2:NP_006554.1 Gene:KLF1 / 10661 HGNCID:6345 Length:362 Species:Homo sapiens


Alignment Length:288 Identity:84/288 - (29%)
Similarity:111/288 - (38%) Gaps:101/288 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   164 GAGGGGGGGGGG-------GGGGGP------PNA---PPLTPPQCSIPAVHPTLLEAMTKNLPLQ 212
            ||..||.|...|       .|...|      |:|   |.|.|    .||..|       |.|.||
Human   114 GAYAGGPGLVAGLLGSEDHSGWVRPALRARAPDAFVGPALAP----APAPEP-------KALALQ 167

  Fly   213 YRNVFAGVLPGKVNS-----------PAASSSPTG--ADFPFRHPLKKCELTWPPPTEQLQLEL- 263
              .|:.|  ||..:|           ||||.:|.|  :.:|         ..:|.|..|...:| 
Human   168 --PVYPG--PGAGSSGGYFPRTGLSVPAASGAPYGLLSGYP---------AMYPAPQYQGHFQLF 219

  Fly   264 -----PHPNPKLSPVL-----PHPQLQDYQTRRKNKARTAATGGNATPNLP-------------- 304
                 |.|.|..||..     |               .|..||...|...|              
Human   220 RGLQGPAPGPATSPSFLSCLGP---------------GTVGTGLGGTAEDPGVIAETAPSKRGRR 269

  Fly   305 ---QRNKDRYTCKF--CGKVFPRSANLTRHLRTHTGEQPYKCKY--CERSFSISSNLQRHVRNIH 362
               ::.:..:||..  |||.:.:|::|..||||||||:||.|.:  |...|:.|..|.||.|. |
Human   270 SWARKRQAAHTCAHPGCGKSYTKSSHLKAHLRTHTGEKPYACTWEGCGWRFARSDELTRHYRK-H 333

  Fly   363 NKERPFKCEICERCFGQQTNLDRHLKKH 390
            ..:|||:|::|.|.|.:..:|..|:|:|
Human   334 TGQRPFRCQLCPRAFSRSDHLALHMKRH 361

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10348NP_001286059.1 COG5048 300..>363 CDD:227381 27/83 (33%)
zf-C2H2 311..333 CDD:278523 10/23 (43%)
C2H2 Zn finger 313..333 CDD:275368 9/21 (43%)
zf-H2C2_2 325..349 CDD:290200 13/25 (52%)
C2H2 Zn finger 341..362 CDD:275368 8/22 (36%)
zf-H2C2_2 353..377 CDD:290200 11/23 (48%)
zf-C2H2 368..390 CDD:278523 8/21 (38%)
C2H2 Zn finger 370..390 CDD:275368 7/19 (37%)
KLF1NP_006554.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..110
EKLF_TAD1 22..>42 CDD:293437
EKLF_TAD2 59..85 CDD:293438
9aaTAD. /evidence=ECO:0000269|PubMed:31375868 71..79
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 249..271 2/21 (10%)
zf-C2H2 279..303 CDD:278523 10/23 (43%)
COG5048 <281..>361 CDD:227381 35/80 (44%)
C2H2 Zn finger 284..303 CDD:275368 8/18 (44%)
zf-H2C2_2 295..322 CDD:290200 14/26 (54%)
C2H2 Zn finger 311..333 CDD:275368 8/22 (36%)
zf-H2C2_2 325..350 CDD:290200 12/25 (48%)
C2H2 Zn finger 341..361 CDD:275368 7/19 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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