DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10348 and KLF2

DIOPT Version :9

Sequence 1:NP_001286059.1 Gene:CG10348 / 35132 FlyBaseID:FBgn0032707 Length:540 Species:Drosophila melanogaster
Sequence 2:NP_057354.1 Gene:KLF2 / 10365 HGNCID:6347 Length:355 Species:Homo sapiens


Alignment Length:277 Identity:74/277 - (26%)
Similarity:98/277 - (35%) Gaps:101/277 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   165 AGGGGGGGGGGG----------------------GGGGPPNAPPLTPPQCSIPAVHPTLLEAMTK 207
            |.||||.|...|                      |.||.|..||.|||                 
Human   128 ADGGGGYGCAPGLTRGPRGLKREGAPGPAASCMRGPGGRPPPPPDTPP----------------- 175

  Fly   208 NLPLQYRNVFAGVLPGKVNSPAASSSPTGADFPFRHPLKKCELTWPPPTEQLQLELPHPNPKLSP 272
                                    .||.|   |.|.|......::|||........|.|....:|
Human   176 ------------------------LSPDG---PARLPAPGPRASFPPPFGGPGFGAPGPGLHYAP 213

  Fly   273 VLPHPQLQDYQTRRKNKARTAATGGNATP-------------------------NLPQRNKDRYT 312
            ..| |....:.    :.|..||..|.|.|                         :.|::....:|
Human   214 PAP-PAFGLFD----DAAAAAAALGLAPPAARGLLTPPASPLELLEAKPKRGRRSWPRKRTATHT 273

  Fly   313 CKF--CGKVFPRSANLTRHLRTHTGEQPYKCKY--CERSFSISSNLQRHVRNIHNKERPFKCEIC 373
            |.:  |||.:.:|::|..||||||||:||.|.:  |...|:.|..|.||.|. |...|||:|.:|
Human   274 CSYAGCGKTYTKSSHLKAHLRTHTGEKPYHCNWDGCGWKFARSDELTRHYRK-HTGHRPFQCHLC 337

  Fly   374 ERCFGQQTNLDRHLKKH 390
            :|.|.:..:|..|:|:|
Human   338 DRAFSRSDHLALHMKRH 354

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10348NP_001286059.1 COG5048 300..>363 CDD:227381 27/91 (30%)
zf-C2H2 311..333 CDD:278523 10/23 (43%)
C2H2 Zn finger 313..333 CDD:275368 9/21 (43%)
zf-H2C2_2 325..349 CDD:290200 13/25 (52%)
C2H2 Zn finger 341..362 CDD:275368 8/22 (36%)
zf-H2C2_2 353..377 CDD:290200 11/23 (48%)
zf-C2H2 368..390 CDD:278523 8/21 (38%)
C2H2 Zn finger 370..390 CDD:275368 7/19 (37%)
KLF2NP_057354.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..42
9aaTAD. /evidence=ECO:0000269|PubMed:31375868 43..51
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 55..90
Interaction with WWP1. /evidence=ECO:0000250 111..268 37/188 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 120..209 27/124 (22%)
COG5048 <267..350 CDD:227381 34/83 (41%)
zf-C2H2 272..296 CDD:278523 10/23 (43%)
C2H2 Zn finger 274..296 CDD:275368 9/21 (43%)
zf-H2C2_2 288..>310 CDD:290200 12/21 (57%)
C2H2 Zn finger 304..326 CDD:275368 8/22 (36%)
zf-H2C2_2 318..343 CDD:290200 12/25 (48%)
C2H2 Zn finger 334..354 CDD:275368 7/19 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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