DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irk3 and kcnj12a

DIOPT Version :9

Sequence 1:	NP_001137835.2	Gene:	Irk3 / 35131	FlyBaseID:	FBgn0032706	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	XP_005162964.1	Gene:	kcnj12a / 569146	ZFINID:	ZDB-GENE-131126-14	Length:	437	Species:	Danio rerio

Alignment Length:	337	Identity:	123/337 - (36%)
Similarity:	195/337 - (57%)	Gaps:	12/337 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 RRSLNRVMEKNGKENVVFRRIPEKSWRYMRDLVTTLMELEWKYMLTLFLGSYFLSWLLFAALCYV 176
            |:|.||.::|||:.||.|..:.|||.|||.|:.||.:::.|:|||.:|...:.:|||.|....:|
Zfish    41 RKSRNRFVKKNGQCNVQFTNMDEKSQRYMADIFTTCVDIRWRYMLIVFTLVFVISWLAFGLAFWV 105

  Fly   177 VAYSHGDFIFDPVSGKRMGEGVDPCIYGVHSWVAMIIYSVETQTTLGFGEKYASEECPETIFLFV 241
            :|..|||  .|..:|   .:...||:..|:.::|..::|:|||||:|:|.:..:||||..:||.|
Zfish   106 IALLHGD--LDNPAG---DDNFTPCVLQVNGFIAAFLFSIETQTTIGYGFRCVTEECPLAVFLVV 165

  Fly   242 MQMLSAALIEGCMVSVIYAKTARPARQLTKLKFSDKAVICYRDGRLCLLFRVCDPREQQSIESKI 306
            .|.:..::|:..|:..|.||.|||.::...|.||..|||..|||:|||::||.:.|:...:|:.:
Zfish   166 FQSIVGSIIDCFMIGAIMAKMARPKKRAQTLLFSHNAVIAMRDGKLCLMWRVGNLRKSHIVEAHV 230

  Fly   307 RVYIIVDKRTREGETIK-SHVELKL---EGNGEQIILWPDVVCHVIDETSPLSQFTTAKLFNAAQ 367
            |..:|..:.|.|||.|. ..:::.:   :|.....::.|..:.|.||..|||...:...| ..|.
Zfish   231 RAQLIKPRVTTEGEYIPLDQLDINVGFDKGLDRIFLVSPITILHQIDHESPLFGISKQDL-ETAD 294

  Fly   368 FELYVSIVGTSPATAQMTEAKTSYLPREIFWGQRFVNIIHYDAQNERYIVDYENFNRTISVDMPM 432
            ||:.|.:.|...|||...:|::|||..||.||.||..:: ::.:|: |.|||.:|::|..|....
Zfish   295 FEIVVILEGMVEATAMTAQARSSYLASEILWGHRFEPVL-FEEKNQ-YKVDYSHFHKTYEVPSTP 357

  Fly   433 TNPKNDHLKLEY 444
            .....|.::.:|
Zfish   358 RCSAKDMMENKY 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk3	NP_001137835.2	Ion_trans_2	119..432	CDD:304432	117/316 (37%)
kcnj12a	XP_005162964.1	IRK_N	2..47	CDD:285640	3/5 (60%)
kcnj12a	XP_005162964.1	IRK	48..371	CDD:279361	119/330 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020