Protein Alignment Irk3 and KCNJ15

DIOPT Version :9

• Sequence 1: NP_001137835.2
• Gene: Irk3 / 35131
• FlyBaseID: FBgn0032706
• Length: 446
• Species: Drosophila melanogaster
• Sequence 2: NP_001263364.1
• Gene: KCNJ15 / 3772
• HGNCID: 6261
• Length: 375
• Species: Homo sapiens
• Alignment Length: 338
• Identity: 115/338 - (34%)
• Similarity: 191/338 - (56%)
• Gaps: 25/338 - (7%)

  Fly    99 LGSGP--RTSSSDGLRRSLNRVMEKNGKENVVFRRIPEKSWRYMRDLVTTLMELEWKYMLTLFLG 161
            :.|.|  :.::..||:.:..|||.|:|..||...::......|::||.||:::::|:|.||||..
Human     8 MSSTPLVKHTAGAGLKANRPRVMSKSGHSNVRIDKVDGIYLLYLQDLWTTVIDMKWRYKLTLFAA 72

  Fly   162 SYFLSWLLFAALCYVVAYSHGDFIFDPVSGKRMGEGVD---PCIYGVHSWVAMIIYSVETQTTLG 223
            ::.::|.||..:.|.:|:.|||  .:|      ||.:.   |||..|.|.....::|:|:|||:|
Human    73 TFVMTWFLFGVIYYAIAFIHGD--LEP------GEPISNHTPCIMKVDSLTGAFLFSLESQTTIG 129

  Fly   224 FGEKYASEECPETIFLFVMQMLSAALIEGCMVSVIYAKTARPARQLTKLKFSDKAVICYRDGRLC 288
            :|.:..:||||..|||.|.|::...|||..:.....||.|||.::...:|||..|||..::|:||
Human   130 YGVRSITEECPHAIFLLVAQLVITTLIEIFITGTFLAKIARPKKRAETIKFSHCAVITKQNGKLC 194

  Fly   289 LLFRVCDPREQQSIESKIRVYIIVDKRTREGE-------TIKSHVELKLEGNGEQIILWPDVVCH 346
            |:.:|.:.|:...|:.::...::....|:|||       |:|.||:...|   ...::.|....|
Human   195 LVIQVANMRKSLLIQCQLSGKLLQTHVTKEGERILLNQATVKFHVDSSSE---SPFLILPMTFYH 256

  Fly   347 VIDETSPLSQFTTAKLFNAAQFELYVSIVGTSPATAQMTEAKTSYLPREIFWGQRFVNIIHYDAQ 411
            |:||||||...|...| ...:|||.|.:..|..:|:.:.:::|||:|.||:||..||.::.. ::
Human   257 VLDETSPLRDLTPQNL-KEKEFELVVLLNATVESTSAVCQSRTSYIPEEIYWGFEFVPVVSL-SK 319

  Fly   412 NERYIVDYENFNR 424
            |.:|:.|:..|.:
Human   320 NGKYVADFSQFEQ 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk3	NP_001137835.2	Ion_trans_2	119..432	CDD:304432	109/316 (34%)
KCNJ15	NP_001263364.1	IRK	30..171	CDD:395797	54/148 (36%)
		Selectivity filter. /evidence=ECO:0000250	127..132		2/4 (50%)
		IRK_C	178..349	CDD:407551	53/160 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153177
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950