Protein Alignment Irk3 and KCNJ11

DIOPT Version :10

• Sequence 1: NP_001137835.2
• Gene: Irk3 / 35131
• FlyBaseID: FBgn0032706
• Length: 446
• Species: Drosophila melanogaster
• Sequence 2: NP_000516.3
• Gene: KCNJ11 / 3767
• HGNCID: 6257
• Length: 390
• Species: Homo sapiens
• Alignment Length: 339
• Identity: 119/339 - (35%)
• Similarity: 185/339 - (54%)
• Gaps: 17/339 - (5%)

  Fly   112 RRSLNRVMEKNGKENVVFRRIPEKSWRYMRDLVTTLMELEWKYMLTLFLGSYFLSWLLFAALCYV 176
            |:...|.:.|.|..||..:.|.|:. |:::|:.|||::|:|.:.|.:|..|:..||||||...::
Human    29 RQRRARFVSKKGNCNVAHKNIREQG-RFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWL 92

  Fly   177 VAYSHGDFIFDPVSGKRMGEGVDPCIYGVHSWVAMIIYSVETQTTLGFGEKYASEECPETIFLFV 241
            :|::|||..  |..|.     .:||:..:||:.:..::|:|.|.|:|||.:..:||||..|.:.:
Human    93 IAFAHGDLA--PSEGT-----AEPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILI 150

  Fly   242 MQMLSAALIEGCMVSVIYAKTARPARQLTKLKFSDKAVICYRDGRLCLLFRVCDPREQQSIESKI 306
            :|.:...:|...|:..|:.|||:..|:...|.||..|||..|.||||.:.||.|.|:...|.:.|
Human   151 VQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATI 215

  Fly   307 RVYIIVDKRTREGETIKSH-VELKLE---GNGEQIILWPDVVCHVIDETSPLSQFTTAKLFNAAQ 367
            .:.::....:.|||.:..| |::.:|   |.....::.|.::.||||..|||.....:.|.:...
Human   216 HMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQD 280

  Fly   368 FELYVSIVGTSPATAQMTEAKTSYLPREIFWGQRFVNIIHYDAQNERYIVDYENFNRTISVDMPM 432
            .|:.|.:.|....|...|:|:||||..||.||||||.|:  ..::.||.|||..|..|:.|..|:
Human   281 LEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIV--AEEDGRYSVDYSKFGNTVKVPTPL 343

  Fly   433 TNPK---NDHLKLE 443
            ...:   .||..||
Human   344 CTARQLDEDHSLLE 357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk3	NP_001137835.2	IRK	119..265	CDD:460023	51/145 (35%)
		IRK_C	272..432	CDD:465439	60/163 (37%)
KCNJ11	NP_000516.3	IRK	36..174	CDD:460023	51/145 (35%)
		Selectivity filter. /evidence=ECO:0000305	130..135		3/4 (75%)
		IRK_C	181..351	CDD:465439	61/171 (36%)