Protein Alignment Irk3 and KCNJ10

DIOPT Version :9

• Sequence 1: NP_001137835.2
• Gene: Irk3 / 35131
• FlyBaseID: FBgn0032706
• Length: 446
• Species: Drosophila melanogaster
• Sequence 2: NP_002232.2
• Gene: KCNJ10 / 3766
• HGNCID: 6256
• Length: 379
• Species: Homo sapiens
• Alignment Length: 335
• Identity: 110/335 - (32%)
• Similarity: 181/335 - (54%)
• Gaps: 22/335 - (6%)

  Fly   102 GPRTSSSDGLRRSLNRVMEKNGKENVVFRRIPEKSWRYMRDLVTTLMELEWKYMLTLFLGSYFLS 166
            ||      |:||  .||:.|:|:.||....|.:|.:.|::||.||.::::|:|.|.||..::..:
Human    22 GP------GIRR--RRVLTKDGRSNVRMEHIADKRFLYLKDLWTTFIDMQWRYKLLLFSATFAGT 78

  Fly   167 WLLFAALCYVVAYSHGDFI-FDPVSGKRMGEGVDPCIYGVHSWVAMIIYSVETQTTLGFGEKYAS 230
            |.||..:.|:||.:|||.: .||.:..      .||:..||:.....::|:|:|||:|:|.:|.|
Human    79 WFLFGVVWYLVAVAHGDLLELDPPANH------TPCVVQVHTLTGAFLFSLESQTTIGYGFRYIS 137

  Fly   231 EECPETIFLFVMQMLSAALIEGCMVSVIYAKTARPARQLTKLKFSDKAVICYRDGRLCLLFRVCD 295
            ||||..|.|.:.|::...::|..:.....||.|||.::...::||..||:...:|:.||:.||.:
Human   138 EECPLAIVLLIAQLVLTTILEIFITGTFLAKIARPKKRAETIRFSQHAVVASHNGKPCLMIRVAN 202

  Fly   296 PREQQSIESKIRVYIIVDKRTREGETIK-SHVELKLE---GNGEQIILWPDVVCHVIDETSPLSQ 356
            .|:...|..::...::...:|:|||.|: :.|.:..:   .:....::.|....||:||||||..
Human   203 MRKSLLIGCQVTGKLLQTHQTKEGENIRLNQVNVTFQVDTASDSPFLILPLTFYHVVDETSPLKD 267

  Fly   357 FTTAKLFNAAQFELYVSIVGTSPATAQMTEAKTSYLPREIFWGQRFVNIIHYDAQNERYIVDYEN 421
            .....  ....|||.:.:.||..:|:...:.:|||||.||.||..|...|...|.. :||.|:..
Human   268 LPLRS--GEGDFELVLILSGTVESTSATCQVRTSYLPEEILWGYEFTPAISLSASG-KYIADFSL 329

  Fly   422 FNRTISVDMP 431
            |::.:.|..|
Human   330 FDQVVKVASP 339

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk3	NP_001137835.2	Ion_trans_2	119..432	CDD:304432	103/318 (32%)
KCNJ10	NP_002232.2	IRK	31..172	CDD:395797	51/146 (35%)
		Selectivity filter. /evidence=ECO:0000250	128..133		2/4 (50%)
		IRK_C	179..354	CDD:407551	50/164 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153180
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950