DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irk3 and KCNJ9

DIOPT Version :9

Sequence 1:	NP_001137835.2	Gene:	Irk3 / 35131	FlyBaseID:	FBgn0032706	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_004974.2	Gene:	KCNJ9 / 3765	HGNCID:	6270	Length:	393	Species:	Homo sapiens

Alignment Length:	367	Identity:	117/367 - (31%)
Similarity:	195/367 - (53%)	Gaps:	46/367 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 SEQNPTFSFPYAHDWAGSTIELTPDLGSGPRTSSSDGLRRSLNRVMEKNGKENVVFRRIPEKSWR 138
            :::|..||               |.....||       ||...|.:||:|:.||....:.| ::|
Human     2 AQENAAFS---------------PGQEEPPR-------RRGRQRYVEKDGRCNVQQGNVRE-TYR 43

  Fly   139 YMRDLVTTLMELEWKYMLTLFLGSYFLSWLLFAALCYVVAYSHGDFIFDPVSGKRMGEGVD---- 199
            |:.||.|||::|:|:..|..|:.:|.|:||.|.|:.:::||..||.           |.::
Human    44 YLTDLFTTLVDLQWRLSLLFFVLAYALTWLFFGAIWWLIAYGRGDL-----------EHLEDTAW 97

  Fly   200 -PCIYGVHSWVAMIIYSVETQTTLGFGEKYASEECPETIFLFVMQMLSAALIEGCMVSVIYAKTA 263
             ||:..::.:||..::|:||:||:|:|.:..:::|||.|.|.::|.:..:::...||..::.|.:
Human    98 TPCVNNLNGFVAAFLFSIETETTIGYGHRVITDQCPEGIVLLLLQAILGSMVNAFMVGCMFVKIS 162

  Fly   264 RPARQLTKLKFSDKAVICYRDGRLCLLFRVCDPREQQSIESKIRVYIIVDKRTREGETIKSH-VE 327
            :|.::...|.||..||:..|||||||:|||.|.|....:|:.||..:|..::|.|||.|..| .:
Human   163 QPNKRAATLVFSSHAVVSLRDGRLCLMFRVGDLRSSHIVEASIRAKLIRSRQTLEGEFIPLHQTD 227

  Fly   328 LKL---EGNGEQIILWPDVVCHVIDETSPLSQFTTAKLFNAAQFELYVSIVGTSPATAQMTEAKT 389
            |.:   .|:....::.|.|:.|.||..||..: .:.:......||:.|.:.|...||....:|::
Human   228 LSVGFDTGDDRLFLVSPLVISHEIDAASPFWE-ASRRALERDDFEIVVILEGMVEATGMTCQARS 291

  Fly   390 SYLPREIFWGQRFVNIIHYDAQNERYIVDYENFNRTISVDMP 431
            |||..|:.||.||.:::  ..::..|.|||.:|:.|..|..|
Human   292 SYLVDEVLWGHRFTSVL--TLEDGFYEVDYASFHETFEVPTP 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk3	NP_001137835.2	Ion_trans_2	119..432	CDD:304432	108/322 (34%)
KCNJ9	NP_004974.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		8/42 (19%)
		IRK	25..164	CDD:395797	48/150 (32%)
		Selectivity filter. /evidence=ECO:0000250	120..125		2/4 (50%)
		IRK_C	171..334	CDD:407551	59/164 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..393
		PDZ-binding	390..393
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3449
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.970