DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irk3 and KCNJ6

DIOPT Version :9

Sequence 1:	NP_001137835.2	Gene:	Irk3 / 35131	FlyBaseID:	FBgn0032706	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_002231.1	Gene:	KCNJ6 / 3763	HGNCID:	6267	Length:	423	Species:	Homo sapiens

Alignment Length:	368	Identity:	114/368 - (30%)
Similarity:	198/368 - (53%)	Gaps:	39/368 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 PRTSSSDGLRRSLNRVMEKNGKENVVFRRIPEKSWRYMRDLVTTLMELEWKYMLTLFLGSYFLSW 167
            ||..|.|..:|.:.|.:.|:||.||....:.| ::||:.|:.|||::|:|::.|.:|:..|.::|
Human    41 PRHISRDRTKRKIQRYVRKDGKCNVHHGNVRE-TYRYLTDIFTTLVDLKWRFNLLIFVMVYTVTW 104

  Fly   168 LLFAALCYVVAYSHGDF--IFDPVSGKRMGEGVDPCIYGVHSWVAMIIYSVETQTTLGFGEKYAS 230
            |.|..:.:::||..||.  |.||        ...||:..::.:|:..::|:||:||:|:|.:..:
Human   105 LFFGMIWWLIAYIRGDMDHIEDP--------SWTPCVTNLNGFVSAFLFSIETETTIGYGYRVIT 161

  Fly   231 EECPETIFLFVMQMLSAALIEGCMVSVIYAKTARPARQLTKLKFSDKAVICYRDGRLCLLFRVCD 295
            ::|||.|.|.::|.:..:::...||..::.|.::|.::...|.||..|||..|||:|||:|||.|
Human   162 DKCPEGIILLLIQSVLGSIVNAFMVGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGD 226

  Fly   296 PREQQSIESKIRVYIIVDKRTREGETIK-SHVELKL---EGNGEQIILWPDVVCHVIDETSPLSQ 356
            .|....:|:.||..:|..|:|.|||.|. :..::.:   .|:....::.|.::.|.|::.||..:
Human   227 LRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVSPLIISHEINQQSPFWE 291

  Fly   357 FTTAKLFNAAQFELYVSIVGTSPATAQMTEAKTSYLPREIFWGQRFVNIIHYDAQNERYIVDYEN 421
            .:.|:| ...:.|:.|.:.|...||....:|::||:..||.||.||..::  ..::..|.|||.:
Human   292 ISKAQL-PKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVL--TLEDGFYEVDYNS 353

  Fly   422 FNRTISVDMPMTNPK---------------------NDHLKLE 443
            |:.|.....|..:.|                     |.|.:||
Human   354 FHETYETSTPSLSAKELAELASRAELPLSWSVSSKLNQHAELE 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk3	NP_001137835.2	Ion_trans_2	119..432	CDD:304432	102/318 (32%)
KCNJ6	NP_002231.1	IRK	57..196	CDD:395797	46/147 (31%)
		Selectivity filter. /evidence=ECO:0000250	152..157		2/4 (50%)
		IRK_C	203..375	CDD:407551	57/174 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	390..423		4/7 (57%)
		PDZ-binding	420..423
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020