DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irk3 and KCNJ5

DIOPT Version :9

Sequence 1:	NP_001137835.2	Gene:	Irk3 / 35131	FlyBaseID:	FBgn0032706	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_000881.3	Gene:	KCNJ5 / 3762	HGNCID:	6266	Length:	419	Species:	Homo sapiens

Alignment Length:	370	Identity:	114/370 - (30%)
Similarity:	203/370 - (54%)	Gaps:	29/370 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 AHDWAGSTIELTPDLGSGPRTSSSDGLRRSLNRVMEKNGKENVVFRRIPEKSWRYMRDLVTTLME 149
            |.|:.....:.|..|..|         ::...|.|||:||.||....:.| ::||:.||.|||::
Human    29 ARDYVPIATDRTRLLAEG---------KKPRQRYMEKSGKCNVHHGNVQE-TYRYLSDLFTTLVD 83

  Fly   150 LEWKYMLTLFLGSYFLSWLLFAALCYVVAYSHGDFIFDPVSGKRMGEGVDPCIYGVHSWVAMIIY 214
            |:|::.|.:|...|.::||.|..:.:::||..||  .|.|..:   |.: ||:..:..:|:..::
Human    84 LKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGD--LDHVGDQ---EWI-PCVENLSGFVSAFLF 142

  Fly   215 SVETQTTLGFGEKYASEECPETIFLFVMQMLSAALIEGCMVSVIYAKTARPARQLTKLKFSDKAV 279
            |:||:||:|:|.:..:|:|||.|.|.::|.:..:::...||..::.|.::|.::...|.||:.||
Human   143 SIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNAFMVGCMFVKISQPKKRAETLMFSNNAV 207

  Fly   280 ICYRDGRLCLLFRVCDPREQQSIESKIRVYIIVDKRTREGETI---KSHVELKLE-GNGEQIILW 340
            |..||.:|||:|||.|.|....:|:.||..:|..::|:|||.|   ::.:.:..: |:....::.
Human   208 ISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIKSRQTKEGEFIPLNQTDINVGFDTGDDRLFLVS 272

  Fly   341 PDVVCHVIDETSPLSQFTTAKLFNAAQFELYVSIVGTSPATAQMTEAKTSYLPREIFWGQRFVNI 405
            |.::.|.|::.||..:.:.|:| :..:||:.|.:.|...||....:|::||:..|:.||.||..:
Human   273 PLIISHEINQKSPFWEMSQAQL-HQEEFEVVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPV 336

  Fly   406 IHYDAQNERYIVDYENFNRTISVDMP------MTNPKNDHLKLEY 444
            :  ..:...|.|||..|:.|...:.|      :...|.:...|:|
Human   337 L--TLEKGFYEVDYNTFHDTYETNTPSCCAKELAEMKREGRLLQY 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk3	NP_001137835.2	Ion_trans_2	119..432	CDD:304432	105/322 (33%)
KCNJ5	NP_000881.3	IRK	54..193	CDD:366415	50/145 (34%)
		Selectivity filter. /evidence=ECO:0000250	149..154		2/4 (50%)
		IRK_C	200..371	CDD:375232	54/173 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	390..419
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020