DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irk3 and KCNJ2

DIOPT Version :9

Sequence 1:	NP_001137835.2	Gene:	Irk3 / 35131	FlyBaseID:	FBgn0032706	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_000882.1	Gene:	KCNJ2 / 3759	HGNCID:	6263	Length:	427	Species:	Homo sapiens

Alignment Length:	356	Identity:	113/356 - (31%)
Similarity:	198/356 - (55%)	Gaps:	26/356 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 STIELTPDLGSGPRTSSSDGLRRSLNRVMEKNGKENVVFRRIPEKSWRYMRDLVTTLMELEWKYM 155
            :|:.:....|:|  .|.....::..:|.::|:|..||.|..:.||..||:.|:.||.:::.|::|
Human    22 ATMAVANGFGNG--KSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWM 84

  Fly   156 LTLFLGSYFLSWLLFAALCYVVAYSHGDFIFDPVSGKRMGEGVDPCIYGVHSWVAMIIYSVETQT 220
            |.:|..::.||||.|..:.:::|..|||     :...:.|:.   |:..|:|:.|..::|:||||
Human    85 LVIFCLAFVLSWLFFGCVFWLIALLHGD-----LDASKEGKA---CVSEVNSFTAAFLFSIETQT 141

  Fly   221 TLGFGEKYASEECPETIFLFVMQMLSAALIEGCMVSVIYAKTARPARQLTKLKFSDKAVICYRDG 285
            |:|:|.:..::|||..:|:.|.|.:...:|:..::..:.||.|:|.::...|.||..|||..|||
Human   142 TIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDG 206

  Fly   286 RLCLLFRVCDPREQQSIESKIRVYIIVDKRTREGETIK-SHVELKL---EGNGEQIILWPDVVCH 346
            :|||::||.:.|:...:|:.:|..::..:.|.|||.|. ..:::.:   .|.....::.|..:.|
Human   207 KLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVH 271

  Fly   347 VIDETSPLSQFTTAKLFNAAQFELYVSIVGTSPATAQMTEAKTSYLPREIFWGQRFVNII----H 407
            .|||.|||...:...:.| |.||:.|.:.|...|||..|:.::|||..||.||.|:..::    |
Human   272 EIDEDSPLYDLSKQDIDN-ADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKH 335

  Fly   408 YDAQNERYIVDYENFNRTISV-DMPMTNPKN 437
            |      |.|||..|::|..| :.|:.:.::
Human   336 Y------YKVDYSRFHKTYEVPNTPLCSARD 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk3	NP_001137835.2	Ion_trans_2	119..432	CDD:304432	107/321 (33%)
KCNJ2	NP_000882.1	IRK_N	1..47	CDD:400662	4/26 (15%)
		IRK	48..186	CDD:395797	48/145 (33%)
		Selectivity filter. /evidence=ECO:0000250	142..147		2/4 (50%)
		IRK_C	193..366	CDD:407551	59/175 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	384..427
		PDZ-binding. /evidence=ECO:0000255	425..427
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020