DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irk3 and Kcnj14

DIOPT Version :9

Sequence 1:	NP_001137835.2	Gene:	Irk3 / 35131	FlyBaseID:	FBgn0032706	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_733836.1	Gene:	Kcnj14 / 276720	RGDID:	628872	Length:	434	Species:	Rattus norvegicus

Alignment Length:	320	Identity:	111/320 - (34%)
Similarity:	179/320 - (55%)	Gaps:	15/320 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 RSLNRVMEKNGKENVVFRRIPEKSWRYMRDLVTTLMELEWKYMLTLFLGSYFLSWLLFAALCYVV 177
            |...|.::|:|..||.|..:..:..||:.||.||.:::.|::|..||..|:..|||||....:::
  Rat    45 RRRGRFVKKDGHCNVRFVNLGGQGARYLSDLFTTCVDVRWRWMCLLFSCSFLASWLLFGLTFWLI 109

  Fly   178 AYSHGDFIFDPVSGKRMGEGVDPCIYGVHSWVAMIIYSVETQTTLGFGEKYASEECPETIFLFVM 242
            |..|||....|...        ||...|.|::|..::::||||::|:|.:..:||||..:...|:
  Rat   110 ASLHGDLAAPPPPA--------PCFSQVASFLAAFLFALETQTSIGYGVRSVTEECPAAVAAVVL 166

  Fly   243 QMLSAALIEGCMVSVIYAKTARPARQLTKLKFSDKAVICYRDGRLCLLFRVCDPREQQSIESKIR 307
            |.::..:::..:|..:.||.|:|.::...|.||:.||:..||.||||::||.:.|....:|:.:|
  Rat   167 QCIAGCVLDAFVVGAVMAKMAKPKKRNETLVFSENAVVALRDRRLCLMWRVGNLRRSHLVEAHVR 231

  Fly   308 VYIIVDKRTREGETI---KSHVELKLEGNGEQIIL-WPDVVCHVIDETSPLSQFTTAKLFNAAQF 368
            ..::..:.|.|||.|   ...|::..:|..::|.| .|..:.|.||..|||.:...|:|.. |.|
  Rat   232 AQLLQPRVTPEGEYIPLDHQDVDVGFDGGTDRIFLVSPITIVHEIDSASPLYELGRAELAR-ADF 295

  Fly   369 ELYVSIVGTSPATAQMTEAKTSYLPREIFWGQRFVNIIHYDAQNERYIVDYENFNRTISV 428
            ||.|.:.|...|||..|:.::||||.|:.||.||..::.  .:..:|.|||.:|:||..|
  Rat   296 ELVVILEGMVEATAMTTQCRSSYLPGELLWGHRFEPVLF--QRGSQYEVDYRHFHRTYEV 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk3	NP_001137835.2	Ion_trans_2	119..432	CDD:304432	109/314 (35%)
Kcnj14	NP_733836.1	IRK	51..376	CDD:279361	109/314 (35%)
		Selectivity filter. /evidence=ECO:0000250	145..150		1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..434
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020