DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irk3 and Kcnj8

DIOPT Version :9

Sequence 1:	NP_001137835.2	Gene:	Irk3 / 35131	FlyBaseID:	FBgn0032706	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_001317292.1	Gene:	Kcnj8 / 16523	MGIID:	1100508	Length:	424	Species:	Mus musculus

Alignment Length:	322	Identity:	113/322 - (35%)
Similarity:	181/322 - (56%)	Gaps:	12/322 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 RVMEKNGKENVVFRRIPEKSWRYMRDLVTTLMELEWKYMLTLFLGSYFLSWLLFAALCYVVAYSH 181
            |.:.|:|..|:..:.|.|:. |:::|:.|||::|:|::.|.:|..|:..||||||.:.::||::|
Mouse    35 RFIAKSGACNLAHKNIREQG-RFLQDIFTTLVDLKWRHTLVIFTMSFLCSWLLFAIMWWLVAFAH 98

  Fly   182 GDFIFDPVSGKRMGEGVDP--CIYGVHSWVAMIIYSVETQTTLGFGEKYASEECPETIFLFVMQM 244
            ||.......|.....|::.  |:..|.|:.:..::|:|.|.|:|||.:..:||||..|.:.::|.
Mouse    99 GDIYAYMEKGTMEKSGLESAVCVTNVRSFTSAFLFSIEVQVTIGFGGRMMTEECPLAITVLILQN 163

  Fly   245 LSAALIEGCMVSVIYAKTARPARQLTKLKFSDKAVICYRDGRLCLLFRVCDPREQQSIESKIRVY 309
            :...:|...|:..|:.|||:..|:...|.||..|||..|:|:||.:|||.|.|:...|.:.:|:.
Mouse   164 IVGLIINAVMLGCIFMKTAQAHRRAETLIFSRHAVIAVRNGKLCFMFRVGDLRKSMIISASVRIQ 228

  Fly   310 IIVDKRTREGETIKSH-----VELKLEGNGEQIILWPDVVCHVIDETSPLSQFTTAKLFNAAQFE 369
            ::....|.|||.:..|     |:..:|.|...::. |.::|||||:.|||...:...|.| ...|
Mouse   229 VVKKTTTPEGEVVPIHQQDIPVDNPIESNNIFLVA-PLIICHVIDKRSPLYDISATDLAN-QDLE 291

  Fly   370 LYVSIVGTSPATAQMTEAKTSYLPREIFWGQRFVNIIHYDAQNERYIVDYENFNRTISVDMP 431
            :.|.:.|....|...|:|:|||:..||.||.|||:|:  ..:...|.|||..|..|:.|..|
Mouse   292 VIVILEGVVETTGITTQARTSYIAEEIQWGHRFVSIV--TEEEGVYSVDYSKFGNTVRVAAP 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk3	NP_001137835.2	Ion_trans_2	119..432	CDD:304432	112/320 (35%)
Kcnj8	NP_001317292.1	IRK	37..184	CDD:366415	50/147 (34%)
		Selectivity filter. /evidence=ECO:0000250	140..145		3/4 (75%)
		IRK_C	191..363	CDD:375232	61/165 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	373..409
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843285
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950