DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irk3 and Kcnj2

DIOPT Version :9

Sequence 1:	NP_001137835.2	Gene:	Irk3 / 35131	FlyBaseID:	FBgn0032706	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_032451.1	Gene:	Kcnj2 / 16518	MGIID:	104744	Length:	428	Species:	Mus musculus

Alignment Length:	356	Identity:	114/356 - (32%)
Similarity:	196/356 - (55%)	Gaps:	26/356 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 STIELTPDLGSGPRTSSSDGLRRSLNRVMEKNGKENVVFRRIPEKSWRYMRDLVTTLMELEWKYM 155
            :|:.:....|:|  .|.....::..:|.::|:|..||.|..:.||..||:.|:.||.:::.|::|
Mouse    22 ATMAVANGFGNG--KSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWM 84

  Fly   156 LTLFLGSYFLSWLLFAALCYVVAYSHGDFIFDPVSGKRMGEGVDPCIYGVHSWVAMIIYSVETQT 220
            |.:|..::.||||.|..:.:::|..|||.....||        ..|:..|:|:.|..::|:||||
Mouse    85 LVIFCLAFVLSWLFFGCVFWLIALLHGDLDTSKVS--------KACVSEVNSFTAAFLFSIETQT 141

  Fly   221 TLGFGEKYASEECPETIFLFVMQMLSAALIEGCMVSVIYAKTARPARQLTKLKFSDKAVICYRDG 285
            |:|:|.:..::|||..:|:.|.|.:...:|:..::..:.||.|:|.::...|.||..|||..|||
Mouse   142 TIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDG 206

  Fly   286 RLCLLFRVCDPREQQSIESKIRVYIIVDKRTREGETIK-SHVELKL---EGNGEQIILWPDVVCH 346
            :|||::||.:.|:...:|:.:|..::..:.|.|||.|. ..:::.:   .|.....::.|..:.|
Mouse   207 KLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVH 271

  Fly   347 VIDETSPLSQFTTAKLFNAAQFELYVSIVGTSPATAQMTEAKTSYLPREIFWGQRFVNII----H 407
            .|||.|||...:...:.| |.||:.|.:.|...|||..|:.::|||..||.||.|:..::    |
Mouse   272 EIDEDSPLYDLSKQDIDN-ADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKH 335

  Fly   408 YDAQNERYIVDYENFNRTISV-DMPMTNPKN 437
            |      |.|||..|::|..| :.|:.:.::
Mouse   336 Y------YKVDYSRFHKTYEVPNTPLCSARD 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk3	NP_001137835.2	Ion_trans_2	119..432	CDD:304432	108/321 (34%)
Kcnj2	NP_032451.1	IRK_N	2..47	CDD:285640	4/26 (15%)
		IRK	48..373	CDD:279361	109/328 (33%)
		Selectivity filter. /evidence=ECO:0000250	142..147		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..428
		PDZ-binding. /evidence=ECO:0000255	426..428
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020