DRSC/TRiP Functional Genomics Resources

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Protein Alignment Irk3 and Kcnj2

DIOPT Version :10

Sequence 1:NP_001137835.2 Gene:Irk3 / 35131 FlyBaseID:FBgn0032706 Length:446 Species:Drosophila melanogaster
Sequence 2:NP_032451.1 Gene:Kcnj2 / 16518 MGIID:104744 Length:428 Species:Mus musculus


Alignment Length:356 Identity:114/356 - (32%)
Similarity:196/356 - (55%) Gaps:26/356 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    91 STIELTPDLGSGPRTSSSDGLRRSLNRVMEKNGKENVVFRRIPEKSWRYMRDLVTTLMELEWKYM 155
            :|:.:....|:|  .|.....::..:|.::|:|..||.|..:.||..||:.|:.||.:::.|::|
Mouse    22 ATMAVANGFGNG--KSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWM 84

  Fly   156 LTLFLGSYFLSWLLFAALCYVVAYSHGDFIFDPVSGKRMGEGVDPCIYGVHSWVAMIIYSVETQT 220
            |.:|..::.||||.|..:.:::|..|||.....||        ..|:..|:|:.|..::|:||||
Mouse    85 LVIFCLAFVLSWLFFGCVFWLIALLHGDLDTSKVS--------KACVSEVNSFTAAFLFSIETQT 141

  Fly   221 TLGFGEKYASEECPETIFLFVMQMLSAALIEGCMVSVIYAKTARPARQLTKLKFSDKAVICYRDG 285
            |:|:|.:..::|||..:|:.|.|.:...:|:..::..:.||.|:|.::...|.||..|||..|||
Mouse   142 TIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDG 206

  Fly   286 RLCLLFRVCDPREQQSIESKIRVYIIVDKRTREGETIK-SHVELKL---EGNGEQIILWPDVVCH 346
            :|||::||.:.|:...:|:.:|..::..:.|.|||.|. ..:::.:   .|.....::.|..:.|
Mouse   207 KLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVH 271

  Fly   347 VIDETSPLSQFTTAKLFNAAQFELYVSIVGTSPATAQMTEAKTSYLPREIFWGQRFVNII----H 407
            .|||.|||...:...:.| |.||:.|.:.|...|||..|:.::|||..||.||.|:..::    |
Mouse   272 EIDEDSPLYDLSKQDIDN-ADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKH 335

  Fly   408 YDAQNERYIVDYENFNRTISV-DMPMTNPKN 437
            |      |.|||..|::|..| :.|:.:.::
Mouse   336 Y------YKVDYSRFHKTYEVPNTPLCSARD 360

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Irk3NP_001137835.2 IRK 119..265 CDD:460023 49/145 (34%)
IRK_C 272..432 CDD:465439 58/168 (35%)
Kcnj2NP_032451.1 IRK_N 1..47 CDD:462486 4/26 (15%)
IRK 48..186 CDD:460023 49/145 (34%)
Selectivity filter. /evidence=ECO:0000250 142..147 2/4 (50%)
Polyphosphoinositide (PIP2)-binding. /evidence=ECO:0000250|UniProtKB:Q64273 181..208 13/26 (50%)
IRK_C 193..366 CDD:465439 59/175 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 383..428
PDZ-binding. /evidence=ECO:0000255 426..428
Blue background indicates that the domain is not in the aligned region.

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