Protein Alignment Irk3 and Kcnj11

DIOPT Version :9

• Sequence 1: NP_001137835.2
• Gene: Irk3 / 35131
• FlyBaseID: FBgn0032706
• Length: 446
• Species: Drosophila melanogaster
• Sequence 2: NP_034732.1
• Gene: Kcnj11 / 16514
• MGIID: 107501
• Length: 390
• Species: Mus musculus
• Alignment Length: 336
• Identity: 122/336 - (36%)
• Similarity: 189/336 - (56%)
• Gaps: 22/336 - (6%)

  Fly   103 PRTSSSDGLRRSLNRVMEKNGKENVVFRRIPEKSWRYMRDLVTTLMELEWKYMLTLFLGSYFLSW 167
            ||..:.:  ||:  |.:.|.|..||..:.|.|:. |:::|:.|||::|:|.:.|.:|..|:..||
Mouse    24 PRYRTRE--RRA--RFVSKKGNCNVAHKNIREQG-RFLQDVFTTLVDLKWPHTLLIFTMSFLCSW 83

  Fly   168 LLFAALCYVVAYSHGDFIFDPVSGKRMGEGVD-PCIYGVHSWVAMIIYSVETQTTLGFGEKYASE 231
            ||||.:.:::|::|||.        ..|||.: ||:..:||:.:..::|:|.|.|:|||.:..:|
Mouse    84 LLFAMVWWLIAFAHGDL--------APGEGTNVPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTE 140

  Fly   232 ECPETIFLFVMQMLSAALIEGCMVSVIYAKTARPARQLTKLKFSDKAVICYRDGRLCLLFRVCDP 296
            |||..|.:.::|.:...:|...|:..|:.|||:..|:...|.||..|||..|.||||.:.||.|.
Mouse   141 ECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVITLRHGRLCFMLRVGDL 205

  Fly   297 REQQSIESKIRVYIIVDKRTREGETIKSH-VELKLE----GNGEQIILWPDVVCHVIDETSPLSQ 356
            |:...|.:.|.:.::....:.|||.:..| |::.:|    |||..::. |.::.||||..|||..
Mouse   206 RKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNGIFLVA-PLIIYHVIDSNSPLYD 269

  Fly   357 FTTAKLFNAAQFELYVSIVGTSPATAQMTEAKTSYLPREIFWGQRFVNIIHYDAQNERYIVDYEN 421
            ...:.|.:....|:.|.:.|....|...|:|:||||..||.||||||.|:  ..::.||.|||..
Mouse   270 LAPSDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIV--AEEDGRYSVDYSK 332

  Fly   422 FNRTISVDMPM 432
            |..||.|..|:
Mouse   333 FGNTIKVPTPL 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk3	NP_001137835.2	Ion_trans_2	119..432	CDD:304432	116/318 (36%)
Kcnj11	NP_034732.1	IRK	36..174	CDD:395797	52/146 (36%)
		Selectivity filter. /evidence=ECO:0000250	130..135		3/4 (75%)
		IRK_C	181..354	CDD:407551	64/166 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843286
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.950