Protein Alignment Irk3 and Kcnj10

DIOPT Version :10

• Sequence 1: NP_001137835.2
• Gene: Irk3 / 35131
• FlyBaseID: FBgn0032706
• Length: 446
• Species: Drosophila melanogaster
• Sequence 2: XP_006496740.3
• Gene: Kcnj10 / 16513
• MGIID: 1194504
• Length: 476
• Species: Mus musculus
• Alignment Length: 427
• Identity: 123/427 - (28%)
• Similarity: 202/427 - (47%)
• Gaps: 83/427 - (19%)

  Fly    75 EQNPTFSFP-----------YAH-DWAGSTI--------ELTPDLGSGPRTSS------------ 107
            :|:|| .||           .|| .|.|.:|        :::..|.:.|.|.|
Mouse    23 KQDPT-DFPCLGGMDSISPACAHIPWGGGSIYLCGSYVSDISQILSTAPCTLSACAHLYSSVAGL 86

  Fly   108 ----SD----------------------------GLRRSLNRVMEKNGKENVVFRRIPEKSWRYM 140
                ||                            |:||  .||:.|:|:.||....|.:|.:.|:
Mouse    87 GLKESDWQKTQMTSVAKVYYSQTTQTESRPLVAPGIRR--RRVLTKDGRSNVRMEHIADKRFLYL 149

  Fly   141 RDLVTTLMELEWKYMLTLFLGSYFLSWLLFAALCYVVAYSHGDFIFDPVSGKRMGEGVD--PCIY 203
            :||.||.::::|:|.|.||..::..:|.||..:.|:||.:|||.:       .:|...:  ||:.
Mouse   150 KDLWTTFIDMQWRYKLLLFSATFAGTWFLFGVVWYLVAVAHGDLL-------ELGPPANHTPCVV 207

  Fly   204 GVHSWVAMIIYSVETQTTLGFGEKYASEECPETIFLFVMQMLSAALIEGCMVSVIYAKTARPARQ 268
            .||:.....::|:|:|||:|:|.:|.|||||..|.|.:.|::...::|..:.....||.|||.::
Mouse   208 QVHTLTGAFLFSLESQTTIGYGFRYISEECPLAIVLLIAQLVLTTILEIFITGTFLAKIARPKKR 272

  Fly   269 LTKLKFSDKAVICYRDGRLCLLFRVCDPREQQSIESKIRVYIIVDKRTREGETIK-SHVELKLE- 331
            ...::||..||:...:|:.||:.||.:.|:...|..::...::...:|:|||.|: :.|.:..:
Mouse   273 AETIRFSQHAVVASHNGKPCLMIRVANMRKSLLIGCQVTGKLLQTHQTKEGENIRLNQVNVTFQV 337

  Fly   332 --GNGEQIILWPDVVCHVIDETSPLSQFTTAKLFNAAQFELYVSIVGTSPATAQMTEAKTSYLPR 394
              .:....::.|....||:||||||.......  ....|||.:.:.||..:|:...:.:|||||.
Mouse   338 DTASDSPFLILPLTFYHVVDETSPLKDLPLRS--GEGDFELVLILSGTVESTSATCQVRTSYLPE 400

  Fly   395 EIFWGQRFVNIIHYDAQNERYIVDYENFNRTISVDMP 431
            ||.||..|...|...|.. :||.|:..|::.:.|..|
Mouse   401 EILWGYEFTPAISLSASG-KYIADFSLFDQVVKVASP 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk3	NP_001137835.2	IRK	119..265	CDD:460023	50/147 (34%)
		IRK_C	272..432	CDD:465439	50/164 (30%)
Kcnj10	XP_006496740.3	IRK	128..269	CDD:460023	50/147 (34%)
		IRK_C	276..451	CDD:465439	50/164 (30%)