DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irk3 and Kcnj12

DIOPT Version :9

Sequence 1:	NP_001137835.2	Gene:	Irk3 / 35131	FlyBaseID:	FBgn0032706	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	XP_017452453.1	Gene:	Kcnj12 / 117052	RGDID:	621660	Length:	529	Species:	Rattus norvegicus

Alignment Length:	456	Identity:	145/456 - (31%)
Similarity:	229/456 - (50%)	Gaps:	59/456 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 STSMPVKPKPLEQKPLL----RSSEKETVNASDYYPESPGFVRRRRSKAAGDHLETRSEQNPTFS 81
            |..:...|:.|....|.    :|.|.....:|...|..|   :.|:..|:....:......|..|
  Rat    17 SWDLAASPRRLSTPTLATFPWKSQEPGAEMSSQNSPRVP---QPRQPSASWPRQKQHPPLQPRAS 78

  Fly    82 FPYAHDWAGSTIELTPDLGSGPR----------------TSSSDGL------------------- 111
            ...||:.....:.|  ..|.||.                :|..|||
  Rat    79 ATKAHEVPPPGVSL--GAGQGPPDPGMTAASRANPYSIVSSEEDGLHLVTMSGANGFGNGKVHTR 141

  Fly   112 RRSLNRVMEKNGKENVVFRRIPEKSWRYMRDLVTTLMELEWKYMLTLFLGSYFLSWLLFAALCYV 176
            ||..||.::|||:.|:.|..:.|||.||:.|:.||.:::.|:|||.:|..::..|||||..:.:|
  Rat   142 RRCRNRFVKKNGQCNIEFANMDEKSQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGIIFWV 206

  Fly   177 VAYSHGDFIFDPVSGKRMGEGVDPCIYGVHSWVAMIIYSVETQTTLGFGEKYASEECPETIFLFV 241
            :|.:|||  .:|..|:    |..||:..||.::|..::|:|||||:|:|.:..:||||..:|:.|
  Rat   207 IAVAHGD--LEPAEGR----GRTPCVLQVHGFMAAFLFSIETQTTIGYGLRCVTEECPVAVFMVV 265

  Fly   242 MQMLSAALIEGCMVSVIYAKTARPARQLTKLKFSDKAVICYRDGRLCLLFRVCDPREQQSIESKI 306
            .|.:...:|:..|:..|.||.|||.::...|.||..||:..|||:|||::||.:.|:...:|:.:
  Rat   266 AQSIVGCIIDSFMIGAIMAKMARPKKRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVEAHV 330

  Fly   307 RVYIIVDKRTREGETIK-SHVELKL---EGNGEQIILWPDVVCHVIDETSPLSQFTTAKLFNAAQ 367
            |..:|..:.|.|||.|. ..:::.:   :|.....::.|..:.|.|||.|||...:...| ....
  Rat   331 RAQLIKPRVTEEGEYIPLDQIDIDVGFDKGLDRIFLVSPITILHEIDEASPLFGISRQDL-ETDD 394

  Fly   368 FELYVSIVGTSPATAQMTEAKTSYLPREIFWGQRFVNIIHYDAQNERYIVDYENFNRTISVDMPM 432
            ||:.|.:.|...|||..|:|::|||..||.||.||..:: ::.:|: |.:||.:|::|..|  |.
  Rat   395 FEIVVILEGMVEATAMTTQARSSYLANEILWGHRFEPVL-FEEKNQ-YKIDYSHFHKTYEV--PS 455

  Fly   433 T 433
            |
  Rat   456 T 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk3	NP_001137835.2	Ion_trans_2	119..432	CDD:304432	116/316 (37%)
Kcnj12	XP_017452453.1	IRK_N	105..148	CDD:285640	7/42 (17%)
Kcnj12	XP_017452453.1	IRK	149..476	CDD:279361	118/319 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020