DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irk3 and kcnj14

DIOPT Version :9

Sequence 1:	NP_001137835.2	Gene:	Irk3 / 35131	FlyBaseID:	FBgn0032706	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_001313403.1	Gene:	kcnj14 / 100526806	ZFINID:	ZDB-GENE-100922-48	Length:	542	Species:	Danio rerio

Alignment Length:	472	Identity:	141/472 - (29%)
Similarity:	229/472 - (48%)	Gaps:	65/472 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 AAATDSLTMHRSTSMPVKPKPLEQKPLL--------RSSEKETVNASDYY-----PESPGFVRR- 60
            |.:.|..:.|..|    .|.|.....:|        ||.|::.....|..     .|..|..||
Zfish    27 AQSDDGTSSHSGT----LPSPNCNGKVLSILHSNGGRSGERDEDEDDDDADKDDDDEEEGGGRRG 87

  Fly    61 ---RRSKAAGDH-LETRSEQNPTFSFPYAHDWAGSTIELTPDLGSGPRTSSSDGLRRSLNRVMEK 121
               |.|..:|:. :|.|.|:|...|.|        ::..|| |....|.|     ||...|.:.|
Zfish    88 GGGRGSALSGESGVEGRWERNKRASLP--------SLSPTP-LRDRRRQS-----RRPRRRFVGK 138

  Fly   122 NGKENVVFRRIPEKSWRYMRDLVTTLMELEWKYMLTLFLGSYFLSWLLFAALCYVVAYSHGDF-- 184
            :|:.||.|..:.|:..||:.||.||.:::.|::||.:|..|:.|:||||....:::|.:|||.
Zfish   139 DGRCNVTFVNMSERGQRYLTDLFTTCVDIRWRWMLVVFTLSFLLTWLLFGFTFWLIAAAHGDLNP 203

  Fly   185 ----------------IFDPVSG----KRMGEGVDPCIYGVHSWVAMIIYSVETQTTLGFGEKYA 229
                            ..|...|    :.:.|..:||...|:|::|..::|:||||::|:|.:..
Zfish   204 LASSSSSPSSLSSSLAPLDATEGSSRVEMVAETEEPCFQQVNSFMAAFLFSLETQTSIGYGFRSV 268

  Fly   230 SEECPETIFLFVMQMLSAALIEGCMVSVIYAKTARPARQLTKLKFSDKAVICYRDGRLCLLFRVC 294
            :|.||..:...|:|.:...:|:..::..:.||.|:|.::...|.|||.||:..|||:||:::||.
Zfish   269 TEACPLAVLAVVLQCIVGCIIDAFIIGAVMAKIAKPKKRNETLVFSDVAVVAVRDGKLCMMWRVG 333

  Fly   295 DPREQQSIESKIRVYIIVDKRTREGETI---KSHVELKLEGNGEQIIL-WPDVVCHVIDETSPLS 355
            :.|:...:|:.:|..::..:.|.|||.:   .|.:.:..:...::|.| .|..:.|.|:|.||..
Zfish   334 NLRKSHLVEAHVRAQLLKPRVTPEGEFLPLDNSDLNVGFDTGTDRIFLVSPVTIVHEINEESPFF 398

  Fly   356 QFTTAKLFNAAQFELYVSIVGTSPATAQMTEAKTSYLPREIFWGQRFVNIIHYDAQNERYIVDYE 420
            :.....|......|:.|.:.|...|||..|:.::|:|..||.||.||..:: ::.:| .|.|||.
Zfish   399 EMDKGALEGDKDLEVVVILEGMVEATAMTTQCRSSFLASEILWGHRFEPVL-FERKN-CYQVDYS 461

  Fly   421 NFNRTISV-DMPMTNPK 436
            .||||..| |.|..:.|
Zfish   462 YFNRTYEVTDTPTCSAK 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk3	NP_001137835.2	Ion_trans_2	119..432	CDD:304432	107/339 (32%)
kcnj14	NP_001313403.1	IRK	136..492	CDD:307239	109/345 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.020