DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irk3 and kcnj14

DIOPT Version :9

Sequence 1:	NP_001137835.2	Gene:	Irk3 / 35131	FlyBaseID:	FBgn0032706	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	XP_002935044.1	Gene:	kcnj14 / 100498359	XenbaseID:	XB-GENE-490027	Length:	433	Species:	Xenopus tropicalis

Alignment Length:	338	Identity:	119/338 - (35%)
Similarity:	191/338 - (56%)	Gaps:	11/338 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 RSLNRVMEKNGKENVVFRRIPEKSWRYMRDLVTTLMELEWKYMLTLFLGSYFLSWLLFAALCYVV 177
            |..:|.::|:|..||.|..:.|||.||:.||.||.:::.|::|..:|..::.:|||:|....:::
Frog    46 RQRSRFVQKDGHCNVEFINLSEKSQRYLTDLFTTCVDIRWRWMFLIFSFTFVVSWLIFGFTFWLI 110

  Fly   178 AYSHGDFIFDPVSGKRMGEGVDPCIYGVHSWVAMIIYSVETQTTLGFGEKYASEECPETIFLFVM 242
            |..|||....|..|....... ||...|.|::|..::|:||||::|:|.:..:||||..:...|:
Frog   111 ASLHGDLAPPPEPGSEEAHNA-PCFLQVTSFMAAFLFSLETQTSIGYGFRSVTEECPMAVLTVVL 174

  Fly   243 QMLSAALIEGCMVSVIYAKTARPARQLTKLKFSDKAVICYRDGRLCLLFRVCDPREQQSIESKIR 307
            |.:...:|:..::..|.||.|:|.::...|.|::.|||..||.:|||::||.:.|:...:|:.:|
Frog   175 QCIVGCIIDAFIIGAIMAKIAKPKKRNETLVFTENAVIALRDEKLCLMWRVANLRKSHLVEAHVR 239

  Fly   308 VYIIVDKRTREGETIK-SHVELKL---EGNGEQIILWPDVVCHVIDETSPLSQFTTAKLFNAAQF 368
            ..::..:.|.|||.:. .|.::.:   .|.....::.|..:.|.|||.|||.:....:| .||.|
Frog   240 AQLLQPRVTPEGEYLPLDHTDINVGFDSGTDRIFLVSPVTIVHEIDEESPLYEIGKEEL-EAANF 303

  Fly   369 ELYVSIVGTSPATAQMTEAKTSYLPREIFWGQRFVNIIHYDAQNERYIVDYENFNRTISVDMPMT 433
            ||.|.:.|...|||..|:.::||||.||.||.||..:: ::.:| .|.|||.:||.|..|  |.|
Frog   304 ELVVILEGMVEATAMTTQCRSSYLPSEILWGSRFEPVL-FEKRN-YYEVDYLHFNSTYEV--PST 364

  Fly   434 NPKNDHLKLEYRK 446
             |.....:|..||
Frog   365 -PTCSAKELSERK 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk3	NP_001137835.2	Ion_trans_2	119..432	CDD:304432	111/316 (35%)
kcnj14	XP_002935044.1	IRK	52..197	CDD:366415	50/145 (34%)
kcnj14	XP_002935044.1	IRK_C	204..377	CDD:375232	66/179 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020