Protein Alignment Irk3 and kcnj12

DIOPT Version :10

• Sequence 1: NP_001137835.2
• Gene: Irk3 / 35131
• FlyBaseID: FBgn0032706
• Length: 446
• Species: Drosophila melanogaster
• Sequence 2: XP_012826624.1
• Gene: kcnj12 / 100496092
• XenbaseID: XB-GENE-6048235
• Length: 421
• Species: Xenopus tropicalis
• Alignment Length: 326
• Identity: 119/326 - (36%)
• Similarity: 194/326 - (59%)
• Gaps: 14/326 - (4%)

  Fly   112 RRSLNRVMEKNGKENVVFRRIPEKSWRYMRDLVTTLMELEWKYMLTLFLGSYFLSWLLFAALCYV 176
            |:..||.::|||:.||.|..:.:||.||:.|:.||.:::.|:|||.:|..::..|||||..:.::
 Frog    39 RKCRNRFVKKNGQCNVQFANMDDKSQRYIADMFTTCVDIRWRYMLIIFCLAFLASWLLFGLIFWL 103

  Fly   177 VAYSHGDFIFDPVSGKRMGEGVDPCIYGVHSWVAMIIYSVETQTTLGFGEKYASEECPETIFLFV 241
            :|:.|||  .:..||   .....||:..|:.::|..::|:|||||:|:|.:..:||||..:|:.|
 Frog   104 IAFVHGD--LENPSG---DTDFKPCVVQVNGFMAAFLFSIETQTTIGYGFRCVTEECPLAVFMVV 163

  Fly   242 MQMLSAALIEGCMVSVIYAKTARPARQLTKLKFSDKAVICYRDGRLCLLFRVCDPREQQSIESKI 306
            .|.:...:|:..|:..|.||.|||.::...|.||..|||..|||:|.|::||.:.|:...:|:.:
 Frog   164 FQSIVGCIIDSFMIGAIMAKMARPKKRAQTLLFSHNAVIAMRDGKLSLMWRVGNLRKSHIVEAHV 228

  Fly   307 RVYIIVDKRTREGETIK-SHVELKL---EGNGEQIILWPDVVCHVIDETSPLSQFTTAKLFNAAQ 367
            |..:|..:.|.|||.|. ..:::.:   :|.....::.|..:.|.|||.|||...:...| ..::
 Frog   229 RAQLIKHRITEEGEYIPLDQIDMNVGFDKGLDRIFLVSPITIVHEIDEESPLFGISKQDL-ETSE 292

  Fly   368 FELYVSIVGTSPATAQMTEAKTSYLPREIFWGQRFVNIIHYDAQNERYIVDYENFNRTISVDMPM 432
            ||:.|.:.|...|||..|:|::|||..||.||.||..:: ::.:|: |.|||.:|::|..|  |.
 Frog   293 FEIVVILEGMVEATAMTTQARSSYLANEILWGHRFEPVL-FEERNQ-YRVDYSHFHKTYEV--PS 353

  Fly   433 T 433
            |
 Frog   354 T 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irk3	NP_001137835.2	IRK	119..265	CDD:460023	54/145 (37%)
		IRK_C	272..432	CDD:465439	58/163 (36%)
kcnj12	XP_012826624.1	IRK_N	1..45	CDD:462486	2/5 (40%)
		IRK	46..187	CDD:460023	54/145 (37%)
		IRK_C	194..366	CDD:465439	60/166 (36%)