DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irk3 and kcnj15

DIOPT Version :9

Sequence 1:	NP_001137835.2	Gene:	Irk3 / 35131	FlyBaseID:	FBgn0032706	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	XP_004919636.1	Gene:	kcnj15 / 100486399	XenbaseID:	XB-GENE-5794036	Length:	377	Species:	Xenopus tropicalis

Alignment Length:	338	Identity:	111/338 - (32%)
Similarity:	194/338 - (57%)	Gaps:	16/338 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 RVMEKNGKENVVFRRIPEKSWRYMRDLVTTLMELEWKYMLTLFLGSYFLSWLLFAALCYVVAYSH 181
            ||:.|:|..||...::......|::||.||:::::|:|.||||..::||:|..|..:.:|||:.|
Frog    36 RVISKSGHSNVKIDKVEGVFLLYLQDLWTTVIDMKWRYKLTLFAATFFLTWCFFGVIYFVVAFIH 100

  Fly   182 GDFIFDPVSGKRMGEGVDPCIYGVHSWVAMIIYSVETQTTLGFGEKYASEECPETIFLFVMQMLS 246
            ||...:|:|..      .||:..|.|:....::|:|:|||:|:|.::.:||||..||:.|.|::.
Frog   101 GDMNIEPLSNH------TPCVMNVDSFTGAFLFSMESQTTIGYGFRFITEECPLAIFMLVAQLVV 159

  Fly   247 AALIEGCMVSVIYAKTARPARQLTKLKFSDKAVICYRDGRLCLLFRVCDPREQQSIESKIRVYII 311
            ..|||..:.....||.|||.::...:|||:||||...:|:|||:.:|.:.|:...|:.::...::
Frog   160 TTLIEIFITGTFLAKIARPKKRAETIKFSNKAVITKHNGKLCLVVQVANMRKSLLIQCQLYGKLL 224

  Fly   312 VDKRTREGETI---KSHVELKLEGNGEQ-IILWPDVVCHVIDETSPLSQFTTAKLFNAAQFELYV 372
            ....|:|||.|   :.::...::.:.|. .::.|....||:|:.|||... ||.......|||.|
Frog   225 HSYETKEGEKILLQQVNMNFNVDSSSESPFLILPLTFYHVLDDNSPLKDL-TADNIKTKDFELVV 288

  Fly   373 SIVGTSPATAQMTEAKTSYLPREIFWGQRFVNIIHYDAQNERYIVDYENFNR----TISVDMPMT 433
            .:..|..:|:.:.:::|||||.||:||..||.::....|. :|:.|:.||::    .:...:.:.
Frog   289 LLNATVESTSTVCQSRTSYLPDEIYWGYEFVPVVSLSPQG-KYVADFSNFDKIRKCKVIETIYLV 352

  Fly   434 NPKNDHLKLEYRK 446
            |.:...|:.:||:
Frog   353 NFEKRKLEEKYRQ 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk3	NP_001137835.2	Ion_trans_2	119..432	CDD:304432	105/320 (33%)
kcnj15	XP_004919636.1	IRK	38..178	CDD:366415	52/145 (36%)
kcnj15	XP_004919636.1	IRK_C	185..342	CDD:375232	51/158 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020