DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Irk3 and KCNJ18

DIOPT Version :9

Sequence 1:	NP_001137835.2	Gene:	Irk3 / 35131	FlyBaseID:	FBgn0032706	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	XP_005276976.1	Gene:	KCNJ18 / 100134444	HGNCID:	39080	Length:	535	Species:	Homo sapiens

Alignment Length:	464	Identity:	145/464 - (31%)
Similarity:	229/464 - (49%)	Gaps:	80/464 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 QSDASPLGAAATDSLTMHRSTSMPVKPKPLEQKPLLRSSEKE------TVNASDYY--------- 51
            :|.|.|        |:.|     .::..|..|.|..|..:|:      .|.|...:
Human    41 ESGAEP--------LSQH-----SLRGPPCRQLPTSRPRQKQCPPFRPCVPAPQRHGAALPGASL 92

  Fly    52 -----PESPGFVRRRRS--------KAAGDHLETRSEQNPTFSFPYAHDWAGSTIELTPDLGSGP 103
                 |.:||.....|:        :..|.||.|.|..|                    ..|:|.
Human    93 GVSQGPPTPGMTAASRANPYSIVSLEEDGLHLVTMSGAN--------------------GFGNGK 137

  Fly   104 RTSSSDGLRRSLNRVMEKNGKENVVFRRIPEKSWRYMRDLVTTLMELEWKYMLTLFLGSYFLSWL 168
            ..:.    ||..||.::|||:.|:.|..:.|||.||:.|:.||.:::.|:|||.:|..::..|||
Human   138 VHTR----RRCRNRFVKKNGQCNIAFANMDEKSQRYLADMFTTCVDIRWRYMLLIFSLAFLASWL 198

  Fly   169 LFAALCYVVAYSHGDFIFDPVSGKRMGEGVDPCIYGVHSWVAMIIYSVETQTTLGFGEKYASEEC 233
            ||..:.:|:|.:|||  .:|..    |.|..||:..||.::|..::|:|||||:|:|.:..:|||
Human   199 LFGVIFWVIAVAHGD--LEPAE----GHGRTPCVMQVHGFMAAFLFSIETQTTIGYGLRCVTEEC 257

  Fly   234 PETIFLFVMQMLSAALIEGCMVSVIYAKTARPARQLTKLKFSDKAVICYRDGRLCLLFRVCDPRE 298
            ...:|:.|.|.:...:|:..|:..|.||.|||.::...|.||..||:..|||:|||::||.:.|:
Human   258 LVAVFMVVAQSIVGCIIDSFMIGAIMAKMARPKKRAQTLLFSHNAVVALRDGKLCLMWRVGNLRK 322

  Fly   299 QQSIESKIRVYIIVDKRTREGETIK-SHVELKL---EGNGEQIILWPDVVCHVIDETSPLSQFTT 359
            ...:|:.:|..:|..:.|.|||.|. ..:::.:   :|.....::.|..:.|.|||.|||...:.
Human   323 SHIVEAHVRAQLIKPRVTEEGEYIPLDQIDIDVGFDKGLDRIFLVSPITILHEIDEASPLFGISR 387

  Fly   360 AKLFNAAQFELYVSIVGTSPATAQMTEAKTSYLPREIFWGQRFVNIIHYDAQNERYIVDYENFNR 424
            ..| ....||:.|.:.|...|||..|:|::|||..||.||.||..:: ::.:|: |.:||.:|::
Human   388 QDL-ETDDFEIVVILEGMVEATAMTTQARSSYLANEILWGHRFEPVL-FEEKNQ-YKIDYSHFHK 449

  Fly   425 TISVDMPMT 433
            |..|  |.|
Human   450 TYEV--PST 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irk3	NP_001137835.2	Ion_trans_2	119..432	CDD:304432	115/316 (36%)
KCNJ18	XP_005276976.1	IRK_N	105..148	CDD:285640	12/66 (18%)
KCNJ18	XP_005276976.1	IRK	149..476	CDD:279361	117/319 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D289862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11767
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020