DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip71 and nedd1

DIOPT Version :9

Sequence 1:	NP_609902.3	Gene:	Grip71 / 35130	FlyBaseID:	FBgn0032705	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_001072456.2	Gene:	nedd1 / 779911	XenbaseID:	XB-GENE-489625	Length:	672	Species:	Xenopus tropicalis

Alignment Length:	700	Identity:	155/700 - (22%)
Similarity:	259/700 - (37%)	Gaps:	148/700 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DFADLETKSEY-VHQNAEPTDFQFNGQRRVFVEVDKMAG--LAVMRIKEKDGKTPEIQRVRKLTI 75
            |::.:....:: .|..:.|...........|:.....:|  :.|...|.|.....|:...:|.|
Frog    36 DYSSMTMVEQFNPHNTSHPVSSLCWSSNNHFLVTASGSGDKIVVSSCKSKPVPLLELAEGKKQT- 99

  Fly    76 DNAFCVACAKQSLEEIAVGQSGCVKLYNFRTAQLIHRFPADPQRSTVLYMDYNNTDEYIAAVRDG 140
                ||.....|...::.|....|.:::.::.:| ||...| .:..|..:.:|..|.|:|:....
Frog   100 ----CVNLNSSSQYVVSGGLDNTVNIWDLKSKRL-HRSLKD-HKDEVTCVTFNANDCYVASGSMS 158

  Fly   141 GDISILGTKTKQKTNTFTIDGDSTLVR---FHPSKRFHLSIASYKGAVTVYDVQGMRKIFHASE- 201
            |:| ||...|...::|....|.|..:|   :...|:..|...|..|:||::|...... :|..|
Frog   159 GEI-ILHNVTTNLSSTPFGHGSSQPIRHLKYSYVKKSLLGTVSDSGSVTLWDANSQNP-YHVFES 221

  Fly   202 AHSAPCRDISMCTSQPALLVSVGYDCKINIFDIRRNRAQASTDRLTYSHPLSTVALSECGTYLCA 266
            ||.||...|........|||::|.|.:|..:|:   .::.....:....||:.|.....|..|..
Frog   222 AHKAPASGICFSPVNDLLLVTIGLDKRIICYDV---SSKILLQTVVAESPLTAVDFMPDGATLAV 283

  Fly   267 GNLKGELIAYDMRSTKAPLAVRSVHDAAVTRVAFVPVPSGDNQQNGSLNSSENATGLATEAPRVE 331
            |:.:|::..||:|...:|:...|.|..:|..:.|.........:..|..||..:|.       |.
Frog   284 GSSRGKIYLYDLRMLSSPVKTVSAHKTSVQCIQFQHSNIYKLSKGPSSKSSITSTS-------VN 341

  Fly   332 RAPSDELRKSIAANLLSTQ------NQLTSLGYGVSTPTIVRRDSFCEFLDAQGPRAVD-----R 385
            :.||   .|:.|....||.      :.::||...|..            :|::||...|     .
Frog   342 KKPS---TKTAAGGTNSTNITKDFPSAISSLPQPVMP------------VDSKGPGVNDDKPGFP 391

  Fly   386 MSTRLGASYRDSFDW-ETLNRKPQPYETANRQSL---CPPVASG--------------------- 425
            .||.|........|: :|.:.|  ..|:..|.||   ..||...
Frog   392 RSTSLDIIPSKETDFAKTSDLK--SIESFGRSSLGDIFSPVRDDASHFRGTEDLASKGNDLDYLA 454

  Fly   426 -----PSSVDNSVNSSTT----ESLQQTLSGPLKDRSNISGDGKLMKIAETDELCEEQSANISVA 481
                 |:|..|.|.::|.    ..|...:..|:|:... |.|.:|    :|..| :.|..:...:
Frog   455 HFNTIPASRRNPVGANTQGIHGSPLHLIIGSPIKEEDE-SQDSEL----KTRNL-QHQQQDFRES 513

  Fly   482 SSTGGGSDKE--NPPPV-------DAEMKRRLRLLSASRNSTPHH----------ANITPQSSNP 527
            ||.....|:.  |..||       :|..|...::||..::..|.|          |.:|.|.::.
Frog   514 SSKPASIDQNNLNDLPVNSVTRTPEAVEKAGHQILSQLKSDVPAHGTKVASPKVVATMTTQLASS 578

  Fly   528 LL-KPQQLLA--KSSSGLSA-------QMDADWRKEFSEL--RDFVDQRCEKVERELEYVTFSNQ 580
            |. |....||  |:.:.|:|       .|..:...:|.|.  ||.|:.:.|.:::      |..|
Frog   579 LSEKIADTLAGDKTGAPLTAIQINFIKNMIEETLDDFREACHRDIVNLQVEMIKQ------FHIQ 637

  Fly   581 RLLANKMTNYMDQQVENTREIRDALALLLQGDSFMREFSRLQNENEMLKA 630
                             :.||:..|......:|.:.|..:|:.||:.|:|
Frog   638 -----------------SSEIQMLLERYSLNESLVAEIEKLREENKRLRA 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip71	NP_609902.3	WD40	57..302	CDD:295369	64/248 (26%)
		WD40 repeat	78..114	CDD:293791	8/35 (23%)
		WD40	<92..302	CDD:225201	56/213 (26%)
		WD40 repeat	123..158	CDD:293791	10/34 (29%)
		WD40 repeat	165..201	CDD:293791	9/38 (24%)
		WD40 repeat	207..234	CDD:293791	7/26 (27%)
		WD40 repeat	252..289	CDD:293791	10/36 (28%)
nedd1	NP_001072456.2	WD40	<21..328	CDD:225201	70/303 (23%)
		WD40	52..317	CDD:238121	67/276 (24%)
		WD40 repeat	56..95	CDD:293791	6/38 (16%)
		WD40 repeat	99..135	CDD:293791	9/41 (22%)
		WD40 repeat	141..178	CDD:293791	10/37 (27%)
		WD40 repeat	183..220	CDD:293791	9/37 (24%)
		WD40 repeat	228..264	CDD:293791	8/38 (21%)
		WD40 repeat	269..306	CDD:293791	10/36 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007355
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8116
SonicParanoid	1	1.000	-	-		X5476
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.030